Phenotypes associated with this allele

• Allele Symbol: Mgrn1^em1(IMPC)Tcp
• Allele Name: endonuclease-mediated mutation 1, The Centre for Phenogenomics
• Allele ID: MGI:6156581
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mgrn1^em1(IMPC)Tcp/Mgrn1^em1(IMPC)Tcp	C57BL/6NCrl-Mgrn1^em1(IMPC)Tcp/Tcp	MGI:6288577
ht2	Mgrn1^em1(IMPC)Tcp/Mgrn1^+	C57BL/6NCrl-Mgrn1^em1(IMPC)Tcp/Tcp	MGI:6394326

Genotype
MGI:6288577

hm1

• Allelic Composition: Mgrn1^em1(IMPC)Tcp/Mgrn1^em1(IMPC)Tcp
• Genetic Background: C57BL/6NCrl-Mgrn1^em1(IMPC)Tcp/Tcp

Data Sources

IMPC Data for Mgrn1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal cranium morphology ( J:211773 )

♂

IMPC - TCP

endocrine/exocrine glands

abnormal pancreas morphology ( J:211773 )

♀

IMPC - TCP

hearing/vestibular/ear

abnormal ear morphology ( J:211773 )

♂

IMPC - TCP

abnormal auditory brainstem response ( J:211773 )

IMPC - TCP

hematopoietic system

increased mean corpuscular hemoglobin ( J:211773 )

♂

IMPC - TCP

homeostasis/metabolism

increased circulating bilirubin level ( J:211773 )

♂

IMPC - TCP

increased circulating alkaline phosphatase level ( J:211773 )

♂

IMPC - TCP

immune system

enlarged lymph nodes ( J:211773 )

♂

IMPC - TCP

integument

abnormal coat/hair pigmentation ( J:211773 )

♂

IMPC - TCP

abnormal skin morphology ( J:211773 )

♀

IMPC - TCP

abnormal skin coloration ( J:211773 )

♂

IMPC - TCP

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - TCP

pigmentation

abnormal coat/hair pigmentation ( J:211773 )

♂

IMPC - TCP

skeleton

abnormal cranium morphology ( J:211773 )

♂

IMPC - TCP

abnormal sternum morphology ( J:211773 )

♂

IMPC - TCP

abnormal bone structure ( J:211773 )

♂

IMPC - TCP

decreased bone mineral content ( J:211773 )

♂

IMPC - TCP

Genotype
MGI:6394326

ht2

• Allelic Composition: Mgrn1^em1(IMPC)Tcp/Mgrn1⁺
• Genetic Background: C57BL/6NCrl-Mgrn1^em1(IMPC)Tcp/Tcp

Data Sources

IMPC Data for Mgrn1

behavior/neurological

increased freezing behavior ( J:211773 )

♀

IMPC - TCP

cardiovascular system

increased heart weight ( J:211773 )

IMPC - TCP

shortened QRS complex duration ( J:211773 )

IMPC - TCP

growth/size/body

increased heart weight ( J:211773 )

IMPC - TCP

enlarged urinary bladder ( J:211773 )

♂

IMPC - TCP

increased spleen weight ( J:211773 )

♂

IMPC - TCP

hematopoietic system

increased spleen weight ( J:211773 )

♂

IMPC - TCP

increased neutrophil cell number ( J:211773 )

IMPC - TCP

decreased lymphocyte cell number ( J:211773 )

♂

IMPC - TCP

increased lymphocyte cell number ( J:211773 )

♀

IMPC - TCP

immune system

increased spleen weight ( J:211773 )

♂

IMPC - TCP

increased neutrophil cell number ( J:211773 )

IMPC - TCP

decreased lymphocyte cell number ( J:211773 )

♂

IMPC - TCP

increased lymphocyte cell number ( J:211773 )

♀

IMPC - TCP

renal/urinary system

enlarged urinary bladder ( J:211773 )

♂

IMPC - TCP

reproductive system

abnormal uterus morphology ( J:211773 )

♀

IMPC - TCP