Phenotypes associated with this allele

• Allele Symbol: Fdx2^{em1(IMPC)Rbrc}
• Allele Name: endonuclease-mediated mutation 1, RIKEN BioResource Center
• Allele ID: MGI:6156129
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fdx2^em1(IMPC)Rbrc/Fdx2^em1(IMPC)Rbrc	C57BL/6-Fdx2^em1(IMPC)Rbrc	MGI:7855532
hm2	Fdx2^em1(IMPC)Rbrc/Fdx2^em1(IMPC)Rbrc	C57BL/6NJcl-Fdx2^em1(IMPC)Rbrc/Rbrc	MGI:7414893
ht3	Fdx2^em1(IMPC)Rbrc/Fdx2^+	C57BL/6-Fdx2^em1(IMPC)Rbrc	MGI:7855537

Genotype
MGI:7855532

hm1

• Allelic Composition: Fdx2^{em1(IMPC)Rbrc}/Fdx2^{em1(IMPC)Rbrc}
• Genetic Background: C57BL/6-Fdx2^{em1(IMPC)Rbrc}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:360976 )

• however, embryonic development appears unaffected

• median survival time is significantly shorter than that for wild-type controls (87 weeks versus 117 weeks, respectively)

growth/size/body

increased susceptibility to age related obesity ( J:360976 )

• mice become visibly fattier than wild-type controls

liver/biliary system

hepatic steatosis ( J:360976 )

• 5 of 19 mice develop liver steatosis

neoplasm

increased tumor incidence ( J:360976 )

• 9 of 19 mice develop spontaneous tumors

Genotype
MGI:7414893

hm2

• Allelic Composition: Fdx2^{em1(IMPC)Rbrc}/Fdx2^{em1(IMPC)Rbrc}
• Genetic Background: C57BL/6NJcl-Fdx2^{em1(IMPC)Rbrc}/Rbrc

Data Sources

IMPC Data for Fdx2

cardiovascular system

abnormal heart weight ( J:211773 )

♀

IMPC - RBRC

digestive/alimentary system

abnormal duodenum morphology ( J:211773 )

IMPC - RBRC

abnormal jejunum morphology ( J:211773 )

♀

IMPC - RBRC

growth/size/body

increased kidney weight ( J:211773 )

♀

IMPC - RBRC

enlarged spleen ( J:211773 )

IMPC - RBRC

increased spleen weight ( J:211773 )

♀

IMPC - RBRC

hematopoietic system

decreased erythrocyte cell number ( J:211773 )

♀

IMPC - RBRC

decreased hemoglobin content ( J:211773 )

♀

IMPC - RBRC

increased large unstained cell number ( J:211773 )

♀

IMPC - RBRC

abnormal spleen morphology ( J:211773 )

IMPC - RBRC

enlarged spleen ( J:211773 )

IMPC - RBRC

increased spleen weight ( J:211773 )

♀

IMPC - RBRC

immune system

increased large unstained cell number ( J:211773 )

♀

IMPC - RBRC

abnormal spleen morphology ( J:211773 )

IMPC - RBRC

enlarged spleen ( J:211773 )

IMPC - RBRC

increased spleen weight ( J:211773 )

♀

IMPC - RBRC

liver/biliary system

abnormal liver morphology ( J:211773 )

♀

IMPC - RBRC

renal/urinary system

increased kidney weight ( J:211773 )

♀

IMPC - RBRC

Genotype
MGI:7855537

ht3

• Allelic Composition: Fdx2^{em1(IMPC)Rbrc}/Fdx2⁺
• Genetic Background: C57BL/6-Fdx2^{em1(IMPC)Rbrc}

mortality/aging

premature death ( J:360976 )

• however, embryonic development appears unaffected

• median survival time is significantly shorter than that for wild-type controls (86 weeks versus 117 weeks, respctively)

growth/size/body

increased susceptibility to age related obesity ( J:360976 )

• mice become visibly fattier than wild-type controls

liver/biliary system

hepatic steatosis ( J:360976 )

• 16 of 33 mice develop liver steatosis

neoplasm

increased tumor incidence ( J:360976 )

• 15 of 33 mice develop spontaneous tumors