About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox10tm8.1Weg
targeted mutation 8.1, Michael Wegner
MGI:6154154
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sox10tm8.1Weg/Sox10tm8.1Weg involves: 129P2/OlaHsd * C3H MGI:6154159
ht2
 		Sox10tm8.1Weg/Sox10+ involves: 129P2/OlaHsd * C3H MGI:6154203


Genotype
MGI:6154159
hm1
Allelic
Composition		 Sox10tm8.1Weg/Sox10tm8.1Weg
Genetic
Background		 involves: 129P2/OlaHsd * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm8.1Weg mutation (0 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:260791 )
• mice die immediately after birth

nervous system
abnormal nervous system morphology ( J:260791 )
• peripheral nerves are thinner in CNS-proximal regions and sometimes appear defasciculated in more distal regions
decreased Schwann cell number ( J:260791 )
• Schwann cells are reduced in numbers in spinal nerves at E18.5
abnormal Schwann cell physiology ( J:260791 )
• marker analysis indicates that the remaining Schwann cells are severely delayed in their capacity to differentiate or are incapable of differentiation
abnormal oligodendrocyte physiology ( J:260791 )
• the number of Mbp and Plp-1 expressing oligodendrocytes are reduced at E18.5, indicating a delay in oligodendroglial differentiation
• however, oligodendroglial cells in the spinal cord appear normal at E18.5




Genotype
MGI:6154203
ht2
Allelic
Composition		 Sox10tm8.1Weg/Sox10+
Genetic
Background		 involves: 129P2/OlaHsd * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm8.1Weg mutation (0 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
megacolon ( J:260791 )
• fewer than 5% of mice succumb to a megacolon around time of weaning

integument
belly spot ( J:260791 )
• fully penetrant white belly spot from second generation backcross to C3H and onwards

nervous system
abnormal oligodendrocyte physiology ( J:260791 )
• the number of Mbp and Plp-1 expressing oligodendrocytes are reduced in the spinal cord at P3 but not later times, indicating a slight and transient delay in oligodendroglial differentiation during the first postnatal days
• however, sciatic nerves, development and maintenance of Schwann cells and PNS myelin, and spinal cord development appear normal

pigmentation
belly spot ( J:260791 )
• fully penetrant white belly spot from second generation backcross to C3H and onwards




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory