Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Magee2em1(IMPC)Wtsi mutation
(1 available);
any
Magee2 mutation
(7 available)
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nervous system
N |
• on a coronal brain section at Bregma +0.98 mm, females show a general trend towards reduction of brain structure sizes, esp. for the lateral ventricle (-43%), suggesting sexual dimorphism in neuroanatomy; however, brain size reduction does not reach statistical significance
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Magee2em1(IMPC)Wtsi mutation
(1 available);
any
Magee2 mutation
(7 available)
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nervous system
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• total brain area is increased by +13%
• width of the brain is increased by +9%
• height of rostral brain is increased by +9%
• height of caudal brain is increased by +7%
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• area of the anterior part of the anterior commissure is increased by +11%
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• area of the superior colliculus is increased by +14%
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• height of the pons is increased by +6%
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• granular retrosplenial cortex total area is significantly enlarged (+34%) due to a combined increase in total cell count (+18%) and average cell area (+14%); as a result, measured cell
density is lower than that in wild-type controls (-12%)
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• area of the granular retrosplenial cortex is the most severely affected brain structure showing an enlargement of +34%
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• area of the hippocampal fimbria is increased by +27%
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• height of the primary motor cortex is increased by +11%
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growth/size/body
N |
• at 4 to 16 weeks of age, hemizygous males exhibit no significant alterations in body weight relative to wild-type controls
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• on a parasagittal brain section at plane Lateral +0.60 mm, hemizygous males display mild to severe brain anomalies reminiscent of macrocephaly at 16 weeks of age
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