Analysis Tools|
Allele Symbol Allele Name Allele ID |
Nf1tm1.1Kest targeted mutation 1.1, Robert A Kesterson MGI:6153136 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• embryos fail to develop past E9.5
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• embryos display pericardial effusions at E10.5
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• embryos display pericardial effusions at E10.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• paralysis in one or both hind limbs begins at approximately 4 months of age, with 55.6% of mice showing paralysis by 5 months of age
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• 81.5% of mice exhibit neurofibroma tumors; tumors arise at the dorsal root ganglia, with invasion of the neural foramen and lead to compression of the spinal cord
• most tumors are detected in cervical and thoracic spine, with a lower percentage in the lumbar spine
• neurofibromas are characterized by disorganized Remak bundles and enriched deposition of collagen
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• 81.5% of mice exhibit neurofibroma tumors; tumors arise at the dorsal root ganglia, with invasion of the neural foramen and lead to compression of the spinal cord
• most tumors are detected in cervical and thoracic spine, with a lower percentage in the lumbar spine
• neurofibromas are characterized by disorganized Remak bundles and enriched deposition of collagen
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• enlarged peripheral nerves
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• enlarged spinal nerve roots
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| neurofibromatosis 1 | DOID:0111253 |
OMIM:162200 |
J:234172 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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