Phenotypes associated with this allele

• Allele Symbol: Cwc22^em1(IMPC)Mbp
• Allele Name: endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• Allele ID: MGI:6152452
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cwc22^em1(IMPC)Mbp/Cwc22^em1(IMPC)Mbp	C57BL/6NCrl-Cwc22^em1(IMPC)Mbp/Mmucd	MGI:6262229
ht2	Cwc22^em1(IMPC)Mbp/Cwc22^+	C57BL/6NCrl-Cwc22^em1(IMPC)Mbp/Mmucd	MGI:6262228

Genotype
MGI:6262229

hm1

• Allelic Composition: Cwc22^em1(IMPC)Mbp/Cwc22^em1(IMPC)Mbp
• Genetic Background: C57BL/6NCrl-Cwc22^em1(IMPC)Mbp/Mmucd

Data Sources

IMPC Data for Cwc22

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - UCD

prenatal lethality prior to heart atrial septation ( J:211773 )

IMPC - UCD

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

Genotype
MGI:6262228

ht2

• Allelic Composition: Cwc22^em1(IMPC)Mbp/Cwc22⁺
• Genetic Background: C57BL/6NCrl-Cwc22^em1(IMPC)Mbp/Mmucd

Data Sources

IMPC Data for Cwc22

cardiovascular system

hemorrhage ( J:211773 )

IMPC - UCD

embryo

spina bifida ( J:211773 )

IMPC - UCD

growth/size/body

microcephaly ( J:211773 )

IMPC - UCD

hematopoietic system

abnormal spleen morphology ( J:211773 )

♀

IMPC - UCD

homeostasis/metabolism

increased circulating aspartate transaminase level ( J:211773 )

♀

IMPC - UCD

immune system

abnormal spleen morphology ( J:211773 )

♀

IMPC - UCD

limbs/digits/tail

polydactyly ( J:211773 )

IMPC - UCD

syndactyly ( J:211773 )

IMPC - UCD

liver/biliary system

abnormal liver morphology ( J:211773 )

IMPC - UCD

nervous system

spina bifida ( J:211773 )

IMPC - UCD

renal/urinary system

cystolithiasis ( J:211773 )

♂

IMPC - UCD

urinary bladder obstruction ( J:211773 )

♂

IMPC - UCD

skeleton

increased bone mineral content ( J:211773 )

♀

IMPC - UCD

vision/eye

microphthalmia ( J:211773 )

IMPC - UCD

anophthalmia ( J:211773 )

IMPC - UCD