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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ddctm1Umon
targeted mutation 1, Umrao Monani
MGI:6151137
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ddctm1Umon/Ddctm1Umon B6.129S(FVB)-Ddctm1Umon MGI:6188070
hm2
 		Ddctm1Umon/Ddctm1Umon FVB.129S(B6)-Ddctm1Umon MGI:6188072
hm3
 		Ddctm1Umon/Ddctm1Umon involves: 129S/SvEv * C57BL/6 * FVB/N MGI:6188064


Genotype
MGI:6188070
hm1
Allelic
Composition		 Ddctm1Umon/Ddctm1Umon
Genetic
Background		 B6.129S(FVB)-Ddctm1Umon
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddctm1Umon mutation (1 available); any Ddc mutation (126 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:250494 )
• no homozygotes are produced from a heterozygote x heterozygote mating




Genotype
MGI:6188072
hm2
Allelic
Composition		 Ddctm1Umon/Ddctm1Umon
Genetic
Background		 FVB.129S(B6)-Ddctm1Umon
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddctm1Umon mutation (1 available); any Ddc mutation (126 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:250494 )
• no homozygotes are produced from a heterozygote x heterozygote mating




Genotype
MGI:6188064
hm3
Allelic
Composition		 Ddctm1Umon/Ddctm1Umon
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddctm1Umon mutation (1 available); any Ddc mutation (126 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired coordination ( J:250494 )
• decreased latency to fall on rotarod is detected between 11 and 12 weeks of age
abnormal maternal nurturing ( J:250494 )
• homozygous females exhibit poor maternal care

embryo
abnormal embryo development ( J:250494 )
• some E15.5 embryos appear poorly developed
decreased embryo size ( J:250494 )
• some E15.5 embryos appear shriveled
abnormal embryonic tissue morphology ( J:250494 )
• some E15.5 embryos appear grossly dysmorphic

growth/size/body
decreased embryo size ( J:250494 )
• some E15.5 embryos appear shriveled

homeostasis/metabolism
impaired adaptive thermogenesis ( J:250494 )
• mice are sensitive to cold exposure, exhibiting lower body temperatures than controls and a longer recovery period
decreased dopamine level ( J:250494 )
• 25% reduction in dopamine levels in the striatum
• however, dopaminergic cells are not altered in number or morphology
decreased serotonin level ( J:250494 )
• 60% reduction in serotonin levels

mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:250494 )
• fewer homozygotes (8%) are produced than expected from a heterozygote x heterozygote mating

reproductive system




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory