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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cyth2tm1c(EUCOMM)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:6150927
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cyth2tm1c(EUCOMM)Wtsi/Cyth2tm1c(EUCOMM)Wtsi
Tg(Mpz-cre)26Mes/0 		involves: C57BL/6N * FVB/NTac MGI:6151124


Genotype
MGI:6151124
cn1
Allelic
Composition		 Cyth2tm1c(EUCOMM)Wtsi/Cyth2tm1c(EUCOMM)Wtsi
Tg(Mpz-cre)26Mes/0
Genetic
Background		 involves: C57BL/6N * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyth2tm1c(EUCOMM)Wtsi mutation (0 available); any Cyth2 mutation (21 available)
Tg(Mpz-cre)26Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:260347 )
N
• sciatic nerve cells exhibit normal proliferation and apoptosis
dysmyelination ( J:260347 )
• reduced myelin thickness in the sciatic nerve of P5 mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory