All Phenotypes Mgme1<tm1.2Lrsn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mgme1^tm1.2Lrsn
targeted mutation 1.2, Nils-Goran Larsson
MGI:6150912

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mgme1^tm1.2Lrsn/Mgme1^tm1.2Lrsn	involves: C57BL/6NTac	MGI:6151397

Allelic Composition	Mgme1^tm1.2Lrsn/Mgme1^tm1.2Lrsn
Genetic Background	involves: C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mgme1^tm1.2Lrsn mutation (0 available); any Mgme1 mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:259702 )

N	• mice exhibit normal fertility and testes morphology

hematopoietic system

anemia ( J:259702 )

• mild than in other mitochondria DNA mutator mice

• moderate at 70 weeks without reticulocytosis

decreased hemoglobin content ( J:259702 )

• mild at 70 weeks

cellular

• depletion and deletion

abnormal mitochondrial physiology ( J:259702 )

• abnormal mitochondrial transcription

• however, mitochondrial protein levels are normal

growth/size/body

growth/size/body region phenotype ( J:259702 )

N	• mice exhibit normal aging

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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