Phenotypes associated with this allele

• Allele Symbol: Tg(Cd68-Fem1a)1Seno
• Allele Name: transgene insertion 1, Hiroshi Seno
• Allele ID: MGI:6150327
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Cd68-Fem1a)1Seno/0	C57BL/6-Tg(Cd68-Fem1a)1Seno	MGI:6151411

Genotype
MGI:6151411

tg1

• Allelic Composition: Tg(Cd68-Fem1a)1Seno/0
• Genetic Background: C57BL/6-Tg(Cd68-Fem1a)1Seno

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:228893 )

N • no spontaneous diarrhea

abnormal digestive system morphology ( J:228893 )

• fewer Ki-67-positive cells and more apoptotic cells in colon tumors compared to wild-type after AOM+DSS-treatment

abnormal colon morphology ( J:228893 )

• reduced colon shortening compared to wild-type after treatment with DSS

• fewer polyps compared to wild-type after treatment with polyp-inducing azoxymethane (AOM) and colitis-inducing dextran sodium sulfate (DSS)

• fewer Ki-67-positive cells and more apoptotic cells in tumors compared to wild-type after AOM+DSS-treatment

abnormal susceptibility to induced colitis ( J:228893 )

• reduced colon shortening compared to wild-type after treatment with DSS

• fewer polyps compared to wild-type after treatment with polyp-inducing azoxymethane (AOM) and colitis-inducing dextran sodium sulfate (DSS)

• fewer Ki-67-positive cells and more apoptotic cells in tumors compared to wild-type after AOM+DSS-treatment

endocrine/exocrine glands

abnormal exocrine gland morphology ( J:228893 )

• reduced loss of crypts of Lieberkuhn in colon compared to wild-type after treatment with DSS

growth/size/body

growth/size/body region phenotype ( J:228893 )

N • gain body weight normally

N • same body weight loss as wild-type after colitis induction with DSS

immune system

abnormal susceptibility to induced colitis ( J:228893 )

• reduced colon shortening compared to wild-type after treatment with DSS

• fewer polyps compared to wild-type after treatment with polyp-inducing azoxymethane (AOM) and colitis-inducing dextran sodium sulfate (DSS)

• fewer Ki-67-positive cells and more apoptotic cells in tumors compared to wild-type after AOM+DSS-treatment

mortality/aging

mortality/aging ( J:228893 )

N • viable and gain body weight normally

N • same mortality rate as wild-type after treatment with colitis-inducing dextran sodium sulfate (DSS)

reproductive system

reproductive system phenotype ( J:228893 )

N • fertile