Phenotypes associated with this allele

• Allele Symbol: Fem1a^tm1Seno
• Allele Name: targeted mutation 1, Hiroshi Seno
• Allele ID: MGI:6150325
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fem1a^tm1Seno/Fem1a^tm1Seno	C57BL/6-Fem1a^tm1Seno	MGI:6151409

Genotype
MGI:6151409

hm1

• Allelic Composition: Fem1a^tm1Seno/Fem1a^tm1Seno
• Genetic Background: C57BL/6-Fem1a^tm1Seno

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal crypts of Lieberkuhn morphology ( J:228893 )

• increased crypt loss after induction of colitis with DSS, also in DSS-treated wild-type and mutant recipients of mutant bone marrow

abnormal colon morphology ( J:228893 )

• significantly elevated accumulation of macrophages, neutrophils, B cells, CD4+ T cells and CD8+ T cells after induction of colitis with 2.5% dextran sodium sulfate (DSS)

• markedly higher levels of pro-inflammatory cytokines and chemokines such as Tnf, Il1b, Il6, Cxcl1 and Ccl2/Mcp1 after induction of colitis with DSS

colon polyps ( J:228893 )

• increased number of polyps at 63 days after treatment with polyp-inducing azoxymethane (AOM) and colitis-inducing dextran sodium sulfate (DSS), also in AOM+DSS-treated wild-type and mutant recipients of mutant bone marrow

• more Ki-67-positive cells and fewer apoptotic cells in tumors after AOM+DSS-treatment

decreased colon length ( J:228893 )

• after induction of colitis with DSS

increased colon tumor incidence ( J:228893 )

• more Ki-67-positive cells and fewer apoptotic cells in tumors after AOM+DSS-treatment

increased susceptibility to induced colitis ( J:228893 )

• after induction with 2.5% dextran sodium sulfate (DSS) and compared to DSS-treated wild-type mice

• higher mortality

• lower body weight

• reduced colon length, also in DSS-treated wild-type and mutant recipients of mutant bone marrow

• significantly elevated accumulation of macrophages, neutrophils, B cells, CD4+ T cells and CD8+ T cells, also in DSS-treated wild-type and mutant recipients of mutant bone marrow

• markedly higher levels of pro-inflammatory cytokines and chemokines such as Tnf, Il1b, Il6, Cxcl1 and Ccl2/Mcp1

• increased histological damage score, also in DSS-treated wild-type and mutant recipients of mutant bone marrow

increased susceptibility to colitis induced morbidity/mortality ( J:228893 )

• after induction of colitis with DSS

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:228893 )

• increased crypt loss after induction of colitis with DSS, also in DSS-treated wild-type and mutant recipients of mutant bone marrow

growth/size/body

decreased body weight ( J:228893 )

• after induction of colitis with DSS

immune system

increased susceptibility to induced colitis ( J:228893 )

• after induction with 2.5% dextran sodium sulfate (DSS) and compared to DSS-treated wild-type mice

• higher mortality

• lower body weight

• reduced colon length, also in DSS-treated wild-type and mutant recipients of mutant bone marrow

• significantly elevated accumulation of macrophages, neutrophils, B cells, CD4+ T cells and CD8+ T cells, also in DSS-treated wild-type and mutant recipients of mutant bone marrow

• markedly higher levels of pro-inflammatory cytokines and chemokines such as Tnf, Il1b, Il6, Cxcl1 and Ccl2/Mcp1

• increased histological damage score, also in DSS-treated wild-type and mutant recipients of mutant bone marrow

increased susceptibility to colitis induced morbidity/mortality ( J:228893 )

• after induction of colitis with DSS

mortality/aging

mortality/aging ( J:228893 )

N • viable

increased susceptibility to colitis induced morbidity/mortality ( J:228893 )

• after induction of colitis with DSS

neoplasm

increased colon tumor incidence ( J:228893 )

• more Ki-67-positive cells and fewer apoptotic cells in tumors after AOM+DSS-treatment

reproductive system

reproductive system phenotype ( J:228893 )

N • fertile