All Phenotypes Samd7<tm1Tfur> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Samd7^tm1Tfur/Samd7^tm1Tfur	involves: 129S6/SvEvTac	MGI:6154235
cx2	Samd11^em1Tfur/Samd11^em1Tfur Samd7^tm1Tfur/Samd7^tm1Tfur	involves: 129S6/SvEvTac	MGI:7520354

Allelic Composition	Samd7^tm1Tfur/Samd7^tm1Tfur
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Samd7^tm1Tfur mutation (1 available); any Samd7 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:253631 )

• morphology of photoreceptor ribbon synapses and of synaptic contacts between photoreceptors and ON bipolar synaptic dendrite tips

• morphology of amacrine, horizontal, Mueller glia, ganglion and bipolar cells

• morphology of retina outer nuclear layer (ONL) at age 12 months

• photopic ERGs elicited by white light stimuli from -0.8 to +1.0 log cdsm^-2 at age 3 months

abnormal retina morphology ( J:253631 )

• expression up-regulation of cone-specific genes and down-regulation of rod-specific genes

abnormal retina rod cell outer segment morphology ( J:253631 )

• ectopic expression of blue cone outer segment marker S-opsin at ages P9 and 10 weeks

• no ectopic expression of green cone outer segment marker M-opsin at age 10 weeks

decreased a-wave amplitude ( J:253631 )

• of scotopic ERG elicited by a +1.0 log cdsm^-2 white light stimulus at age 3 months

decreased b-wave amplitude ( J:253631 )

• of scotopic ERGs elicited by -2.6 and -1.4 log cdsm^-2 white light stimuli at age 3 months

nervous system

abnormal retina rod cell outer segment morphology ( J:253631 )

• ectopic expression of blue cone outer segment marker S-opsin at ages P9 and 10 weeks

• no ectopic expression of green cone outer segment marker M-opsin at age 10 weeks

growth/size/body

growth/size/body region phenotype ( J:253631 )

N	• no gross morphological abnormalities

mortality/aging

mortality/aging ( J:253631 )

N	• viable and born at expected Mendelian ratio

reproductive system

reproductive system phenotype ( J:253631 )

• fertile

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina photoreceptor layer morphology ( J:303740 )

• retinas show wider and more loosely packed discs

abnormal photoreceptor outer segment morphology ( J:303740 )

• retina shows strong S-opsin signals in rod and cone outer segments

short photoreceptor outer segment ( J:303740 )

• retina shows reduced outer segment thickness at 2 months of age

• however, outer nuclear layer thickness is normal at 2 months and no degeneration is seen at 12 months of age

abnormal retina rod cell outer segment morphology ( J:303740 )

• the rod outer segment length is decreased by about 10%

disorganized photoreceptor outer segment ( J:303740 )

• the outer segments are disorganized but the photoreceptor disk structure of the outer segments is unaffected

abnormal eye physiology ( J:303740 )

• mice show lower sensitivity to low-to-moderate flash luminescence than controls and show delayed signal transmission from rods to rod bipolar cells at low flash luminescence

increased b-wave implicit time ( J:303740 )

• the implicit time of the b-wave on dark-adapted ERGs, indicating transduction process speed between rods and bipolar cells, is delayed in 2-month-old mice

• however, light-adapted ERGs show no difference in implicit times of photopic b-waves or a-waves

decreased a-wave amplitude ( J:303740 )

• dark-adapted (scotopic) ERGs show decreased a-wave amplitude at 2 months of age

decreased b-wave amplitude ( J:303740 )

• dark-adapted (scotopic) ERGs show decreased b-wave amplitude at 2 months of age