All Phenotypes Ppp2r2a<igt10> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ppp2r2a^igt10
impaired glucose tolerance 10
MGI:6149954

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ppp2r2a^igt10/Ppp2r2a⁺	involves: C3H/HeH * C57BL/6J	MGI:6160733
cx2	Insr^tm1Dac/Insr⁺ Ppp2r2a^igt10/Ppp2r2a⁺	involves: 129S4/SvJae * C3H/HeH * C57BL/6J	MGI:6160731

Allelic Composition	Ppp2r2a^igt10/Ppp2r2a⁺
Genetic Background	involves: C3H/HeH * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp2r2a^igt10 mutation (0 available); any Ppp2r2a mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:246319 )

homeostasis/metabolism

increased circulating insulin level ( J:246319 )

insulin resistance ( J:246319 )

Allelic Composition	Insr^tm1Dac/Insr⁺ Ppp2r2a^igt10/Ppp2r2a⁺
Genetic Background	involves: 129S4/SvJae * C3H/HeH * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insr^tm1Dac mutation (2 available); any Insr mutation (95 available)
Ppp2r2a^igt10 mutation (0 available); any Ppp2r2a mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hyperglycemia ( J:246319 )

• mice exhibit elevated plasma glucose levels from 18 weeks

increased circulating insulin level ( J:246319 )

• plasma insulin levels are elevated more than in either single heterozygote

impaired glucose tolerance ( J:246319 )

• mice show impaired glucose tolerance at 12 weeks of age

increased urine glucose level ( J:246319 )

• mice exhibit glycosuria by 28 weeks of age

insulin resistance ( J:246319 )

renal/urinary system

increased urine glucose level ( J:246319 )

• mice exhibit glycosuria by 28 weeks of age

behavior/neurological

polydipsia ( J:246319 )

• mice drink more and produce more urine as glycosuria develops

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:246319 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:246319

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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