About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Usp15tm1Pgrs
targeted mutation 1, Phillippe Gross
MGI:6149705
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Usp15tm1Pgrs/Usp15tm1Pgrs Not Specified MGI:6149722
ht2
 		Usp15L749R/Usp15tm1Pgrs involves: 129S1/SvImJ * C57BL/6J MGI:6149723


Genotype
MGI:6149722
hm1
Allelic
Composition		 Usp15tm1Pgrs/Usp15tm1Pgrs
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp15tm1Pgrs mutation (0 available); any Usp15 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are mostly (85% survival) resistant to fatal encephalitis unlike wild-type mice

immune system
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are mostly (85% survival) resistant to fatal encephalitis unlike wild-type mice
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are mostly (85% survival) resistant to fatal encephalitis unlike wild-type mice




Genotype
MGI:6149723
ht2
Allelic
Composition		 Usp15L749R/Usp15tm1Pgrs
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp15L749R mutation (0 available); any Usp15 mutation (57 available)
Usp15tm1Pgrs mutation (0 available); any Usp15 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are resistant (95% survival) to fatal encephalitis unlike wild-type mice

immune system
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are resistant (95% survival) to fatal encephalitis unlike wild-type mice
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are resistant (95% survival) to fatal encephalitis unlike wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory