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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Usp15L749R
L749R
MGI:6149704
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Usp15L749R/Usp15L749R involves: 129S1/SvImJ * C57BL/6J MGI:6149720
ht2
 		Usp15L749R/Usp15+ involves: 129S1/SvImJ * C57BL/6J MGI:6149721
ht3
 		Usp15L749R/Usp15tm1Pgrs involves: 129S1/SvImJ * C57BL/6J MGI:6149723
cx4
 		Trim25tm1Mura/Trim25+
Usp15L749R/Usp15+ 		involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J MGI:6149725


Genotype
MGI:6149720
hm1
Allelic
Composition		 Usp15L749R/Usp15L749R
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp15L749R mutation (0 available); any Usp15 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to bacterial infection induced morbidity/mortality ( J:259382 )
• in a non-microbial model of neuro-inflammation (EAE), mice treated with pertussis toxin exhibit less death than wild-type mice
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are resistant to fatal encephalitis independent of blood-stage replication unlike wild-type mice

immune system
immune system phenotype ( J:259382 )
N
• immune cells stimulated with phorbol ester PMA and ionomycin exhibit normal intracellular cytokine production and reactive oxygen species in neutrophils
abnormal T-helper 1 physiology ( J:259382 )
• L. monocytogenes-infected mice exhibit an increase in maturation and activation of CD4+ T cells in response to listeriolysin compared with wild-type cells
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:259382 )
• in a non-microbial model of neuro-inflammation (EAE), mice treated with pertussis toxin exhibit reduced body weight loss, lower clinical scores and less death with lower serum levels of cytokines (CCL3 and CCL4) than wild-type mice
decreased susceptibility to bacterial infection ( J:259382 )
• in a non-microbial model of neuro-inflammation (EAE), mice treated with pertussis toxin exhibit reduced body weight loss, lower clinical scores and less death with lower serum levels of cytokines (CCL3 and CCL4) than wild-type mice
decreased susceptibility to bacterial infection induced morbidity/mortality ( J:259382 )
• in a non-microbial model of neuro-inflammation (EAE), mice treated with pertussis toxin exhibit less death than wild-type mice
decreased susceptibility to parasitic infection ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are resistant to fatal encephalitis independent of blood-stage replication with reduced leukocyte infiltration and MIP-1beta chemoattractant compared with wild-type mice
• bone marrow cells transferred into an irradiated recipient confers resistance to experimental cerebral malaria
• however, infected mice exhibit normal levels of IL-12p40, TNF, and IFNG
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are resistant to fatal encephalitis independent of blood-stage replication unlike wild-type mice

hematopoietic system
abnormal T-helper 1 physiology ( J:259382 )
• L. monocytogenes-infected mice exhibit an increase in maturation and activation of CD4+ T cells in response to listeriolysin compared with wild-type cells




Genotype
MGI:6149721
ht2
Allelic
Composition		 Usp15L749R/Usp15+
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp15L749R mutation (0 available); any Usp15 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are partially (30% survival) resistant to fatal encephalitis unlike wild-type mice

immune system
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are partially (30% survival) resistant to fatal encephalitis unlike wild-type mice
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are partially (30% survival) resistant to fatal encephalitis unlike wild-type mice




Genotype
MGI:6149723
ht3
Allelic
Composition		 Usp15L749R/Usp15tm1Pgrs
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp15L749R mutation (0 available); any Usp15 mutation (57 available)
Usp15tm1Pgrs mutation (0 available); any Usp15 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are resistant (95% survival) to fatal encephalitis unlike wild-type mice

immune system
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are resistant (95% survival) to fatal encephalitis unlike wild-type mice
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are resistant (95% survival) to fatal encephalitis unlike wild-type mice




Genotype
MGI:6149725
cx4
Allelic
Composition		 Trim25tm1Mura/Trim25+
Usp15L749R/Usp15+
Genetic
Background		 involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim25tm1Mura mutation (1 available); any Trim25 mutation (41 available)
Usp15L749R mutation (0 available); any Usp15 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are increased partially (60% survival) resistant to fatal encephalitis compared with single heterozygotes (20-30% survival)

immune system
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are increased partially (60% survival) resistant to fatal encephalitis compared with single heterozygotes (20-30% survival)
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are increased partially (60% survival) resistant to fatal encephalitis compared with single heterozygotes (20-30% survival)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory