Phenotypes associated with this allele

• Allele Symbol: Pigq^{tm2b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 2b, Wellcome Trust Sanger Institute
• Allele ID: MGI:6148224
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pigq^tm2b(EUCOMM)Wtsi/Pigq^tm2b(EUCOMM)Wtsi	C57BL/6N-Pigq^tm2b(EUCOMM)Wtsi/Bay	MGI:6263163
ht2	Pigq^tm2b(EUCOMM)Wtsi/Pigq^+	C57BL/6N-Pigq^tm2b(EUCOMM)Wtsi/Bay	MGI:6288646

Genotype
MGI:6263163

hm1

• Allelic Composition: Pigq^{tm2b(EUCOMM)Wtsi}/Pigq^{tm2b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Pigq^{tm2b(EUCOMM)Wtsi}/Bay
• Cell Lines: EPD0581_8_H04

Data Sources

IMPC Data for Pigq

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:211773 )

IMPC - BCM

abnormal vitelline vasculature morphology ( J:211773 )

IMPC - BCM

abnormal heart morphology ( J:211773 )

IMPC - BCM

abnormal heart looping ( J:211773 )

IMPC - BCM

abnormal pericardium morphology ( J:211773 )

IMPC - BCM

craniofacial

abnormal pharyngeal arch morphology ( J:211773 )

IMPC - BCM

embryo

abnormal vitelline vasculature morphology ( J:211773 )

IMPC - BCM

abnormal pharyngeal arch morphology ( J:211773 )

IMPC - BCM

abnormal embryo development ( J:211773 )

IMPC - BCM

abnormal embryo turning ( J:211773 )

IMPC - BCM

abnormal left-right axis patterning ( J:211773 )

IMPC - BCM

embryonic growth retardation ( J:211773 )

IMPC - BCM

abnormal embryo size ( J:211773 )

IMPC - BCM

abnormal limb bud morphology ( J:211773 )

IMPC - BCM

abnormal neural tube morphology ( J:211773 )

IMPC - BCM

abnormal neural tube closure ( J:211773 )

IMPC - BCM

abnormal somite shape ( J:211773 )

IMPC - BCM

abnormal tail bud morphology ( J:211773 )

IMPC - BCM

abnormal allantois morphology ( J:211773 )

IMPC - BCM

abnormal visceral yolk sac morphology ( J:211773 )

IMPC - BCM

pale yolk sac ( J:211773 )

♂

IMPC - BCM

abnormal chorioallantoic fusion ( J:211773 )

IMPC - BCM

growth/size/body

embryonic growth retardation ( J:211773 )

IMPC - BCM

abnormal embryo size ( J:211773 )

IMPC - BCM

hearing/vestibular/ear

abnormal otic vesicle morphology ( J:211773 )

IMPC - BCM

homeostasis/metabolism

edema ( J:211773 )

IMPC - BCM

integument

pallor ( J:211773 )

IMPC - BCM

limbs/digits/tail

abnormal limb bud morphology ( J:211773 )

IMPC - BCM

abnormal tail bud morphology ( J:211773 )

IMPC - BCM

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - BCM

preweaning lethality, complete penetrance ( J:211773 )

IMPC - BCM

nervous system

abnormal neural tube morphology ( J:211773 )

IMPC - BCM

abnormal neural tube closure ( J:211773 )

IMPC - BCM

abnormal forebrain development ( J:211773 )

IMPC - BCM

abnormal hindbrain development ( J:211773 )

IMPC - BCM

abnormal midbrain development ( J:211773 )

IMPC - BCM

vision/eye

abnormal optic vesicle formation ( J:211773 )

IMPC - BCM

Genotype
MGI:6288646

ht2

• Allelic Composition: Pigq^{tm2b(EUCOMM)Wtsi}/Pigq⁺
• Genetic Background: C57BL/6N-Pigq^{tm2b(EUCOMM)Wtsi}/Bay
• Cell Lines: EPD0581_8_H04

Data Sources

IMPC Data for Pigq

cardiovascular system

abnormal retina vasculature morphology ( J:211773 )

♂

IMPC - BCM

prolonged PR interval ( J:211773 )

♀

IMPC - BCM

homeostasis/metabolism

impaired glucose tolerance ( J:211773 )

♂

IMPC - BCM

vision/eye

abnormal retina vasculature morphology ( J:211773 )

♂

IMPC - BCM

increased cornea thickness ( J:211773 )

♀

IMPC - BCM

abnormal eye anterior chamber depth ( J:211773 )

♀

IMPC - BCM

abnormal retina inner nuclear layer morphology ( J:211773 )

IMPC - BCM

abnormal retina outer nuclear layer morphology ( J:211773 )

IMPC - BCM

decreased total retina thickness ( J:211773 )

♂

IMPC - BCM