Phenotypes associated with this allele

• Allele Symbol: Brd2^{em1(IMPC)Wtsi}
• Allele Name: endonuclease-mediated mutation 1, Wellcome Trust Sanger Institute
• Allele ID: MGI:6147548
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brd2^em1(IMPC)Wtsi/Brd2^em1(IMPC)Wtsi	C57BL/6N-Brd2^em1(IMPC)Wtsi/WtsiIeg	MGI:6161263
ht2	Brd2^em1(IMPC)Wtsi/Brd2^+	C57BL/6N-Brd2^em1(IMPC)Wtsi/WtsiIeg	MGI:6261996

Genotype
MGI:6161263

hm1

• Allelic Composition: Brd2^{em1(IMPC)Wtsi}/Brd2^{em1(IMPC)Wtsi}
• Genetic Background: C57BL/6N-Brd2^{em1(IMPC)Wtsi}/WtsiIeg

Data Sources

IMPC Data for Brd2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

persistent right dorsal aorta ( J:239583 )

DMDD

persistent trigeminal artery ( J:239583 )

DMDD

retroesophageal right subclavian artery ( J:239583 )

DMDD

interrupted aortic arch, type b ( J:239583 )

DMDD

aorta coarctation ( J:239583 )

DMDD

abnormal common carotid artery morphology ( J:239583 )

DMDD

abnormal external carotid artery origin ( J:239583 )

DMDD

abnormal vertebral artery topology ( J:239583 )

DMDD

artery stenosis ( J:239583 )

DMDD

abnormal brain artery topology ( J:239583 )

DMDD

dilated liver sinusoidal space ( J:239583 )

DMDD

abnormal umbilical vein topology ( J:239583 )

DMDD

abnormal ductus venosus morphology ( J:239583 )

DMDD

abnormal ductus venosus topology ( J:239583 )

DMDD

duplication of ductus venosus ( J:239583 )

DMDD

abnormal hepatic portal vein connection ( J:239583 )

DMDD

dual inferior vena cava ( J:239583 )

DMDD

abnormal pectinate muscle morphology ( J:239583 )

DMDD

absent pectinate muscle ( J:239583 )

DMDD

thin myocardium compact layer ( J:239583 )

DMDD

common truncal valve ( J:239583 )

DMDD

persistent truncus arteriosus ( J:239583 )

DMDD

double outlet right ventricle ( J:239583 )

DMDD

transposition of great arteries ( J:239583 )

DMDD

abnormal interatrial septum morphology ( J:239583 )

DMDD

atrioventricular septal defect ( J:239583 )

DMDD

perimembraneous ventricular septal defect ( J:239583 )

DMDD

muscular ventricular septal defect ( J:239583 )

DMDD

enlarged heart ( J:239583 )

DMDD

abnormal semilunar valve morphology ( J:239583 )

DMDD

abnormal aortic valve morphology ( J:239583 )

DMDD

abnormal pulmonary valve morphology ( J:239583 )

DMDD

hemorrhage ( J:239583 )

DMDD

craniofacial

basisphenoid bone foramen ( J:239583 )

DMDD

abnormal middle ear ossicle morphology ( J:239583 )

DMDD

abnormal nasal septum morphology ( J:239583 )

DMDD

embryo

abnormal umbilical vein topology ( J:239583 )

DMDD

abnormal Mullerian duct topology ( J:239583 )

DMDD

myelocele ( J:239583 )

DMDD

abnormal physiological umbilical hernia morphology ( J:239583 )

DMDD

endocrine/exocrine glands

abnormal adenohypophysis morphology ( J:239583 )

DMDD

abnormal pineal gland morphology ( J:239583 )

DMDD

small thymus ( J:239583 )

DMDD

abnormal thymus topology ( J:239583 )

DMDD

small thyroid gland ( J:239583 )

DMDD

abnormal gallbladder morphology ( J:239583 )

DMDD

growth/size/body

enlarged heart ( J:239583 )

DMDD

abnormal nasal septum morphology ( J:239583 )

DMDD

thoracoschisis ( J:239583 )

DMDD

fetal growth retardation ( J:239583 )

DMDD

heterochrony ( J:239583 )

DMDD

hearing/vestibular/ear

abnormal middle ear ossicle morphology ( J:239583 )

DMDD

hematopoietic system

small thymus ( J:239583 )

DMDD

abnormal thymus topology ( J:239583 )

DMDD

homeostasis/metabolism

retropleural edema ( J:239583 )

DMDD

subcutaneous edema ( J:239583 )

DMDD

immune system

small thymus ( J:239583 )

DMDD

abnormal thymus topology ( J:239583 )

DMDD

absent connection between subcutaneous lymph vessels and lymph sac ( J:239583 )

DMDD

blood in lymph vessels ( J:239583 )

DMDD

integument

subcutaneous edema ( J:239583 )

DMDD

liver/biliary system

dilated liver sinusoidal space ( J:239583 )

DMDD

abnormal gallbladder morphology ( J:239583 )

DMDD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

muscle

abnormal pectinate muscle morphology ( J:239583 )

DMDD

absent pectinate muscle ( J:239583 )

DMDD

thin myocardium compact layer ( J:239583 )

DMDD

absent eye muscles ( J:239583 )

DMDD

nervous system

abnormal brain artery topology ( J:239583 )

DMDD

myelocele ( J:239583 )

DMDD

absent superior cervical ganglion ( J:239583 )

DMDD

reduced sympathetic cervical ganglion size ( J:239583 )

DMDD

enlarged brain ventricles ( J:239583 )

DMDD

abnormal choroid plexus morphology ( J:239583 )

DMDD

abnormal forebrain morphology ( J:239583 )

DMDD

abnormal adenohypophysis morphology ( J:239583 )

DMDD

abnormal pineal gland morphology ( J:239583 )

DMDD

exencephaly ( J:239583 )

DMDD

abnormal vagus ganglion morphology ( J:239583 )

DMDD

abnormal hypoglossal nerve topology ( J:239583 )

DMDD

abnormal olfactory nerve morphology ( J:239583 )

DMDD

abnormal optic chiasm morphology ( J:239583 )

DMDD

absent vagus nerve ( J:239583 )

DMDD

renal/urinary system

small kidney ( J:239583 )

DMDD

respiratory system

abnormal nasal septum morphology ( J:239583 )

DMDD

abnormal lung position or orientation ( J:239583 )

DMDD

skeleton

basisphenoid bone foramen ( J:239583 )

DMDD

abnormal middle ear ossicle morphology ( J:239583 )

DMDD

absent costovertebral joint ( J:239583 )

DMDD

decreased rib number ( J:239583 )

DMDD

increased rib number ( J:239583 )

DMDD

rib bifurcation ( J:239583 )

DMDD

rib fusion ( J:239583 )

DMDD

scoliosis ( J:239583 )

DMDD

abnormal vertebral arch morphology ( J:239583 )

DMDD

absent vertebral arch ( J:239583 )

DMDD

fusion of vertebral arches ( J:239583 )

DMDD

abnormal vertebral body morphology ( J:239583 )

DMDD

vision/eye

absent eye muscles ( J:239583 )

DMDD

abnormal optic chiasm morphology ( J:239583 )

DMDD

aphakia ( J:239583 )

DMDD

abnormal optic cup morphology ( J:239583 )

DMDD

abnormal optic stalk morphology ( J:239583 )

DMDD

Genotype
MGI:6261996

ht2

• Allelic Composition: Brd2^{em1(IMPC)Wtsi}/Brd2⁺
• Genetic Background: C57BL/6N-Brd2^{em1(IMPC)Wtsi}/WtsiIeg

Data Sources

IMPC Data for Brd2

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - WTSI

hematopoietic system

increased mean corpuscular hemoglobin ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

immune system

increased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

skeleton

abnormal vertebral arch morphology ( J:211773 )

IMPC - WTSI