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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nt5c2tm1.1Aafo
targeted mutation 1.1, Adolfo A Ferrando
MGI:6147342
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nt5c2tm1.1Aafo/Nt5c2+
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+ 		involves: 129 * C57BL/6 * SJL MGI:6147350


Genotype
MGI:6147350
cn1
Allelic
Composition		 Nt5c2tm1.1Aafo/Nt5c2+
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Thl mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Nt5c2tm1.1Aafo mutation (0 available); any Nt5c2 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow cell physiology ( J:257751 )
• bone marrow cells used in a transplantation experiment following tamoxifen-induction produce NOTCH1-induced tumors that are resistant to 6-mercaptopurine chemotherapy unlike control cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory