All Phenotypes Mir34a<tm1.1Pisc> MGI Mouse

increased susceptibility to bacterial infection induced morbidity/mortality ( J:256929 )

• opportunistic bacterial infection with gram-negative Pasteurella pneumotropica

• following treatment with a broad-spectrum antibiotic most mice survive

postnatal lethality, incomplete penetrance ( J:256929 )

• about 80% of mice die before 4 weeks of age typically from bacterial infections

• following treatment with a broad-spectrum antibiotic most mice survive and those that survive past 5 weeks have normal lifespan

decreased respiratory motile cilia number ( J:256929 )

• extent of ciliation in the nasal respiratory epithelium is severely reduced

• absence of normal ciliation in the trachea, bronchi, and bronchioles

• monociliated cells of the olfactory epithelium do not appear to be affected

nasal inflammation ( J:256929 )

• show severe inflammation in the nasal cavity

abnormal respiratory epithelium physiology ( J:256929 )

• increase in the fraction of proliferating cells

• increase in proliferating cells is inversely correlated with the decrease in ciliation

abnormal oviduct epithelium motile cilium morphology ( J:256929 )

• strong reduction in the number of multicilia

oligozoospermia ( J:256929 )

• strong reduction of sperm counts in the epididymis

abnormal seminiferous tubule morphology ( J:256929 )

• atrophy of the tubules is seen starting at 5 weeks of age

abnormal efferent ductules of testis morphology ( J:256929 )

• strong reduction in the number of multicilia

abnormal oviduct physiology ( J:256929 )

• increase in the fraction of proliferating cells in the epithelium

• increase in proliferating cells is inversely correlated with the decrease in ciliation

abnormal oviduct transport ( J:256929 )

• 2.5 days after superovulation oocytes remain trapped in the bursa of the ovary

female infertility ( J:256929 )

male infertility ( J:256929 )

• 7 of 8 males were incapable of impregnating wild-type females

postnatal growth retardation ( J:256929 )

• fail to thrive

slow postnatal weight gain ( J:256929 )

• following treatment with a broad-spectrum antibiotic most mice gain weight normally

nervous system phenotype ( J:256929 )

N	• consistent with expression patterns cilia of the brain ventricles do not appear to be affected

renal/urinary system phenotype ( J:256929 )

N	• consistent with expression patterns cilia of the kidney do not appear to be affected

neoplasm ( J:256929 )

N	• no signs of increased tumorigenesis are detected

abnormal oviduct epithelium motile cilium morphology ( J:256929 )

• strong reduction in the number of multicilia

decreased respiratory motile cilia number ( J:256929 )

• extent of ciliation in the nasal respiratory epithelium is severely reduced

• absence of normal ciliation in the trachea, bronchi, and bronchioles

• monociliated cells of the olfactory epithelium do not appear to be affected

oligozoospermia ( J:256929 )

• strong reduction of sperm counts in the epididymis

abnormal seminiferous tubule morphology ( J:256929 )

• atrophy of the tubules is seen starting at 5 weeks of age

nasal inflammation ( J:256929 )

• show severe inflammation in the nasal cavity

increased susceptibility to bacterial infection induced morbidity/mortality ( J:256929 )

• opportunistic bacterial infection with gram-negative Pasteurella pneumotropica

• following treatment with a broad-spectrum antibiotic most mice survive

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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