Phenotypes associated with this allele

• Allele Symbol: Phgdh^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:6120719
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Phgdh^tm1b(KOMP)Wtsi/Phgdh^tm1b(KOMP)Wtsi	C57BL/6N-Phgdh^tm1b(KOMP)Wtsi/Kmpc	MGI:6394355
ht2	Phgdh^tm1b(KOMP)Wtsi/Phgdh^+	C57BL/6N-Phgdh^tm1b(KOMP)Wtsi/Kmpc	MGI:6325164

Genotype
MGI:6394355

hm1

• Allelic Composition: Phgdh^{tm1b(KOMP)Wtsi}/Phgdh^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Phgdh^{tm1b(KOMP)Wtsi}/Kmpc
• Cell Lines: EPD0071_1_A07

Data Sources

IMPC Data for Phgdh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:211773 )

IMPC - KMPC

abnormal vitelline vasculature morphology ( J:211773 )

IMPC - KMPC

hemorrhage ( J:211773 )

IMPC - KMPC

craniofacial

abnormal head shape ( J:211773 )

IMPC - KMPC

embryo

abnormal vitelline vasculature morphology ( J:211773 )

IMPC - KMPC

abnormal embryo development ( J:211773 )

IMPC - KMPC

abnormal embryo turning ( J:211773 )

IMPC - KMPC

embryonic growth retardation ( J:211773 )

IMPC - KMPC

abnormal embryo size ( J:211773 )

IMPC - KMPC

abnormal visceral yolk sac morphology ( J:211773 )

IMPC - KMPC

growth/size/body

abnormal head shape ( J:211773 )

IMPC - KMPC

embryonic growth retardation ( J:211773 )

IMPC - KMPC

abnormal embryo size ( J:211773 )

IMPC - KMPC

abnormal head size ( J:211773 )

IMPC - KMPC

homeostasis/metabolism

edema ( J:211773 )

IMPC - KMPC

mortality/aging

prenatal lethality ( J:211773 )

IMPC - KMPC

preweaning lethality, complete penetrance ( J:211773 )

IMPC - KMPC

nervous system

abnormal hindbrain morphology ( J:211773 )

IMPC - KMPC

vision/eye

abnormal eye morphology ( J:211773 )

IMPC - KMPC

microphthalmia ( J:211773 )

IMPC - KMPC

Genotype
MGI:6325164

ht2

• Allelic Composition: Phgdh^{tm1b(KOMP)Wtsi}/Phgdh⁺
• Genetic Background: C57BL/6N-Phgdh^{tm1b(KOMP)Wtsi}/Kmpc
• Cell Lines: EPD0071_1_A07

Data Sources

IMPC Data for Phgdh

behavior/neurological

decreased fluid intake ( J:211773 )

♀

IMPC - KMPC

decreased food intake ( J:211773 )

♀

IMPC - KMPC

unresponsive to tactile stimuli ( J:211773 )

IMPC - KMPC

no spontaneous movement ( J:211773 )

IMPC - KMPC

homeostasis/metabolism

decreased respiratory quotient ( J:211773 )

♀

IMPC - KMPC

vision/eye

abnormal cornea morphology ( J:211773 )

♀

IMPC - KMPC

cornea opacity ( J:211773 )

♀

IMPC - KMPC