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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mthfd2tm1b(EUCOMM)Wtsi
targeted mutation 1b, Wellcome Trust Sanger Institute
MGI:6120705
Summary 2 genotypes


Genotype
MGI:6262937
hm1
Allelic
Composition		 Mthfd2tm1b(EUCOMM)Wtsi/Mthfd2tm1b(EUCOMM)Wtsi
Genetic
Background		 C57BL/6N-Mthfd2tm1b(EUCOMM)Wtsi/Bay
Cell Lines EPD0752_2_A07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mthfd2tm1b(EUCOMM)Wtsi mutation (0 available); any Mthfd2 mutation (24 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial

embryo
pale yolk sac ( J:211773 )
IMPC - BCM

growth/size/body
abnormal facial morphology ( J:211773 )
IMPC - BCM
embryonic growth retardation ( J:211773 )
IMPC - BCM
abnormal embryo size ( J:211773 )
IMPC - BCM

integument
pallor ( J:211773 )
IMPC - BCM

liver/biliary system
pale liver ( J:211773 )
IMPC - BCM

mortality/aging

skeleton

vision/eye
microphthalmia ( J:211773 )
IMPC - BCM




Genotype
MGI:6288586
ht2
Allelic
Composition		 Mthfd2tm1b(EUCOMM)Wtsi/Mthfd2+
Genetic
Background		 C57BL/6N-Mthfd2tm1b(EUCOMM)Wtsi/Bay
Cell Lines EPD0752_2_A07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mthfd2tm1b(EUCOMM)Wtsi mutation (0 available); any Mthfd2 mutation (24 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

cardiovascular system

vision/eye




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory