Phenotypes associated with this allele

• Allele Symbol: Atp4a^tm1.1Ocalv
• Allele Name: targeted mutation 1.1, Oriol Calvete
• Allele ID: MGI:6118153
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atp4a^tm1.1Ocalv/Atp4a^tm1.1Ocalv	involves: 129S6/SvEv * C57BL/6J * C57BL/6NCrl	MGI:6188978
ht2	Atp4a^tm1.1Ocalv/Atp4a^+	involves: 129S6/SvEv * C57BL/6J * C57BL/6NCrl	MGI:6188982

Genotype
MGI:6188978

hm1

• Allelic Composition: Atp4a^tm1.1Ocalv/Atp4a^tm1.1Ocalv
• Genetic Background: involves: 129S6/SvEv * C57BL/6J * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal stomach morphology ( J:235360 )

• mice show a thickening and increased weight of stomachs and increased mass index of stomach normalized to total weight, with no differences in size index

• corpus thickness is severely increased while antrum thickness is slightly increased

• cellular disorganization in the corpus region of the stomach characterized by the presence of proliferating cells and enterochromaffin-like-cells within the neck region of gastric corpus glands

• gastric corpus show higher cellularity, loss of nuclear polarity, increased number of inflammatory cells, swollen cytoplasms, and loss of normal gland morphology

abnormal stomach glandular region morphology ( J:235360 )

• stomachs show glandular disorganization

abnormal stomach wall morphology ( J:235360 )

• gastric wall hyperplasia

abnormal stomach mucosa morphology ( J:235360 )

• the gastric corpus shows vacuolization of gastric mucosal cells

• mice exhibit stomach hyperplasia, showing increased gastric corpus thickness and increased mass index

• mucosa metaplasia

abnormal gastric gland morphology ( J:235360 )

• dysplastic gastric glands, with loss of architectural integrity of the oxyntic glands in stomachs and widely opened lumen of the oxyntic glands

abnormal gastric parietal cell morphology ( J:235360 )

• dysplastic cytoplasms of parietal cells

gastric cyst ( J:235360 )

• the gastric corpus shows high numbers of epidermoid cysts surrounded by a single layer of cuboidal epithelium

gastric metaplasia ( J:235360 )

• severe hyperplasia, dysplasia and glandular metaplasia in the stomach

• gastric acidification induced by treatment with 3% HCl acid prevents (if treated at birth) or partially reverts (if treated during adulthood) the development of glandular metaplasia and dysplasia in the stomach

achlorhydria ( J:235360 )

increased stomach pH ( J:235360 )

• gastric pH is highly increased (pH 7 compared to pH 1.5-2.5 in controls)

endocrine/exocrine glands

abnormal gastric gland morphology ( J:235360 )

• dysplastic gastric glands, with loss of architectural integrity of the oxyntic glands in stomachs and widely opened lumen of the oxyntic glands

abnormal gastric parietal cell morphology ( J:235360 )

• dysplastic cytoplasms of parietal cells

hematopoietic system

anemia ( J:235360 )

• iron-deficiency anemia is more pronounced in females than males

homeostasis/metabolism

increased circulating gastrin level ( J:235360 )

• 4-fold increase in mean serum gastrin concentration, indicating hypergastrinemia

• high serum gastrin levels persist throughout the day and are not affected by feeding as seen in controls

decreased circulating ferritin level ( J:235360 )

• reduced ferritin levels are more pronounced in females than males

neoplasm

neoplasm ( J:235360 )

N • while mice do not develop gastric neuroendocrine tumors after one year, they exhibit premalignant pathology and cellular dysplasia

growth/size/body

gastric cyst ( J:235360 )

• the gastric corpus shows high numbers of epidermoid cysts surrounded by a single layer of cuboidal epithelium

Genotype
MGI:6188982

ht2

• Allelic Composition: Atp4a^tm1.1Ocalv/Atp4a⁺
• Genetic Background: involves: 129S6/SvEv * C57BL/6J * C57BL/6NCrl

digestive/alimentary system

increased stomach pH ( J:235360 )

• gastric pH is highly increased (pH 4 compared to pH 1.5-2.5 in controls)