Phenotypes associated with this allele

• Allele Symbol: Lacc1^em4Arkr
• Allele Name: endonuclease-mediated mutation 4, Arthur Kaser
• Allele ID: MGI:6118042
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lacc1^em4Arkr/Lacc1^em4Arkr	C57BL/6NTac-Lacc1^em4Arkr	MGI:6118077

Genotype
MGI:6118077

hm1

• Allelic Composition: Lacc1^em4Arkr/Lacc1^em4Arkr
• Genetic Background: C57BL/6NTac-Lacc1^em4Arkr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage physiology ( J:244365 )

• macrophages exhibit decreased basal or maximal uncontrolled oxygen consumption rate compared with Lacc1 and Lacc1 homozygotes

• macrophages exhibit an decreased in glycolysis compared with Lacc1 and Lacc1 homozygotes

increased circulating interleukin-1 beta level ( J:244365 )

• in LPS-treated mice (10 mg per kg body weight)

increased susceptibility to endotoxin shock ( J:244365 )

• in LPS-treated mice (10 mg per kg body weight)

homeostasis/metabolism

increased circulating interleukin-1 beta level ( J:244365 )

• in LPS-treated mice (10 mg per kg body weight)

cellular

abnormal redox activity ( J:244365 )

• decreased extracellular reactive oxygen species in M1 macrophages stimulated with zymosan

hematopoietic system

abnormal macrophage physiology ( J:244365 )

• macrophages exhibit decreased basal or maximal uncontrolled oxygen consumption rate compared with Lacc1 and Lacc1 homozygotes

• macrophages exhibit an decreased in glycolysis compared with Lacc1 and Lacc1 homozygotes