Analysis Tools
mortality/aging
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• homozygotes are embryonic lethal
|
growth/size/body
|
• at E13.5, all embryos show a significant reduction in size and length relative to wild-type and heterozygous controls
|
embryo
|
• at E13.5, all embryos show a significant reduction in size and length relative to wild-type and heterozygous controls
|
|
• at E13.5, all embryos show absence of Mullerian ducts
|
|
• at E13.5, all embryos show absence of Wolffian ducts
|
nervous system
exencephaly
(
J:248902
)
|
• at E13.5, all embryos exhibit exencephaly
|
renal/urinary system
|
• at E13.5, all embryos show bilateral kidney agenesis
• however, mesonephric tubules (a transient kidney structure) are consistently present
|
|
• at E13.5, most embryos show potential remnants of ureteric bud (UB), suggesting that UB had emerged from the Wolffian duct before it degenerates
|
reproductive system
 |
• at E13.5, male gonads show poorly organized sex cords relative to heterozygous controls
|
small testis
(
J:248902
)
|
|
• at E13.5, male gonads are small
|
cardiovascular system
|
• at E13.5, all embryos exhibit cardiac morphogenesis defects, as shown by micro-computed tomography
|
|
• at E13.5, instead of the normal left-right position, heart ventricles are both on the left and rotated by almost 90 degrees, resulting in superimposed ventricles reminiscent of topsy-turvy heart
• however, the atria and great vessels are apparently well formed
|
endocrine/exocrine glands
|
|
• at E13.5, male gonads show poorly organized sex cords relative to heterozygous controls
|
small testis
(
J:248902
)
|
|
• at E13.5, male gonads are small
|
respiratory system
|
• lungs appear normal and well positioned but slightly underdeveloped
|
liver/biliary system
|
• liver appears normal and well positioned but slightly underdeveloped
|
digestive/alimentary system
|
• intestine appears normal and well positioned but slightly underdeveloped
|
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• stomach appears normal and well positioned but slightly underdeveloped
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