Analysis Tools
mortality/aging
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• begin to die around E12.5 with all dead by E14.5
|
cardiovascular system
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• vascular malformations at E13.5
|
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• decreased vascular density at E13.5
|
|
• discontinuous endothelial cell barrier in vessels in the liver at E13.5
|
|
• concentric hypertrophy
|
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• severe hemorrhaging in the brain ventricular space and neural tube at E13.5
|
liver/biliary system
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• at E13.5
|
small liver
(
J:256995
)
|
• considerably smaller at E13.5
|
growth/size/body
|
• concentric hypertrophy
|
|
• slightly smaller than littermate controls after E13.5
|
hematopoietic system
embryo
|
• slightly smaller than littermate controls after E13.5
|
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• fetal capillary bed is ill-defined
|
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• thinner and poorly developed
|
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• display prominent labyrinth trophoblasts arranged in poorly formed maternal vascular spaces
|
nervous system
|
• severe hemorrhaging in the brain ventricular space and neural tube at E13.5
|
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• overall brain disorganization at E13.5
|
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• decreased vascular density at E13.5
|
cellular
|
• at E13.5
|
