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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fbxo7tm1c(EUCOMM)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:6117789
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Fbxo7tm1c(EUCOMM)Wtsi/Fbxo7tm1c(EUCOMM)Wtsi
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6J * C57BL/6N MGI:6286261


Genotype
MGI:6286261
cn1
Allelic
Composition
Fbxo7tm1c(EUCOMM)Wtsi/Fbxo7tm1c(EUCOMM)Wtsi
Tg(Cd4-cre)1Cwi/0
Genetic
Background
involves: C57BL/6J * C57BL/6N
Cell Lines EPD0622_3_D02
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxo7tm1c(EUCOMM)Wtsi mutation (1 available); any Fbxo7 mutation (27 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• surprisingly, mice show no evidence of thymic atrophy or any alterations in T cell development within the thymus
• mice show a mild reduction of T cells in spleen
• however, no alteration is observed in the phenotype of remaining T cells
• mice show a significant reduction of CD8-positive T cell number in spleen

immune system
N
• mice show no weight loss phenotype during the course of infection with Salmonella typhimurium
• mice show a mild reduction of T cells in spleen
• however, no alteration is observed in the phenotype of remaining T cells
• mice show a significant reduction of CD8-positive T cell number in spleen





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory