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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Csgalnact2tm1.2Staka
targeted mutation 1.2, Satoru Takahashi
MGI:6117386
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka involves: C57BL/6J MGI:6117387
cx2
 		Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari
Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka 		involves: C57BL/6J MGI:6117388


Genotype
MGI:6117387
hm1
Allelic
Composition		 Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csgalnact2tm1.2Staka mutation (0 available); any Csgalnact2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:256718 )
• viable and fertile with no gross abnormalities and normal skeletal morphology




Genotype
MGI:6117388
cx2
Allelic
Composition		 Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari
Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csgalnact1tm1.1Nari mutation (0 available); any Csgalnact1 mutation (33 available)
Csgalnact2tm1.2Staka mutation (0 available); any Csgalnact2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:256718 )
• do not survive after birth

respiratory system
respiratory distress ( J:256718 )
• when delivered by cesarean section pups struggle to initiate breathing
respiratory failure ( J:256718 )
• no alveolar air spaces in the lungs indicating mice die of respiratory failure

homeostasis/metabolism

growth/size/body
decreased birth body size ( J:256718 )
decreased birth weight ( J:256718 )
• slightly lower

skeleton
short humerus ( J:256718 )
• length is reduced by 22% compared to controls
• decreased bone length is not seen in either single homozygote
short tibia ( J:256718 )
• length is reduced by 22% compared to controls
• decreased bone length is not seen in either single homozygote
abnormal cartilage morphology ( J:256718 )
• Safranin-O staining indicates drastically decreased glycosaminoglycan content

limbs/digits/tail
short humerus ( J:256718 )
• length is reduced by 22% compared to controls
• decreased bone length is not seen in either single homozygote
short tibia ( J:256718 )
• length is reduced by 22% compared to controls
• decreased bone length is not seen in either single homozygote




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory