Phenotypes associated with this allele

• Allele Symbol: Haus6^tm1.2Sdwb
• Allele Name: targeted mutation 1.2, Sadanori Watanabe
• Allele ID: MGI:6117369
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Haus6^tm1.2Sdwb/Haus6^tm1.2Sdwb	B6N(FVB)-Haus6^tm1.2Sdwb	MGI:6117404
cx2	Gt(ROSA)26Sor^tm12.1Sia/Gt(ROSA)26Sor^+ Haus6^tm1.2Sdwb/Haus6^tm1.2Sdwb	B6.Cg-Haus6^tm1.2Sdwb Gt(ROSA)26Sor^tm12.1Sia	MGI:6117406

Genotype
MGI:6117404

hm1

• Allelic Composition: Haus6^tm1.2Sdwb/Haus6^tm1.2Sdwb
• Genetic Background: B6N(FVB)-Haus6^tm1.2Sdwb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:235084 )

• mice die before E7.5

• however, mice are present at E2.5

embryo

abnormal embryo development ( J:235084 )

• disorganized at the blastocyst stage with frequent mitotic defects

• abnormal spindles from 16 to 32-cell stage before centrosome formation

cellular

abnormal mitotic spindle morphology ( J:235084 )

• abnormal spindles from 16 to 32-cell stage before centrosome formation

Genotype
MGI:6117406

cx2

• Allelic Composition: Gt(ROSA)26Sor^tm12.1Sia/Gt(ROSA)26Sor⁺; Haus6^tm1.2Sdwb/Haus6^tm1.2Sdwb
• Genetic Background: B6.Cg-Haus6^tm1.2Sdwb Gt(ROSA)26Sor^tm12.1Sia

cellular

abnormal mitotic spindle morphology ( J:235084 )

• delayed or incomplete clustering of microtubule-organizing centers in embryonic cells