All Phenotypes Pcdh19<tm1Tac> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pcdh19^tm1Tac
targeted mutation 1, Taconic
MGI:6117336

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pcdh19^tm1Tac/Pcdh19^tm1Tac	involves: 129S/SvEv * C57BL/6	MGI:6117338
ht2	Pcdh19^tm1Tac/Pcdh19⁺	involves: 129S/SvEv * C57BL/6	MGI:6117339
ht3	Pcdh19^tm1Tac/Pcdh19^em1Pqt	involves: 129S/SvEv * C57BL/6	MGI:6117341
ot4	Pcdh19^tm1Tac/Y	involves: 129S/SvEv * C57BL/6	MGI:6117340

Allelic Composition	Pcdh19^tm1Tac/Pcdh19^tm1Tac
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcdh19^tm1Tac mutation (0 available); any Pcdh19 mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:256961 , J:255320 )

N	• despite expression patterns, brain structure appears normal and cells are located in the expected locations (J:256961) • electrocorticograms are indistinguishable from wild-type controls at P42 (J:255320)

abnormal neuronal migration ( J:256961 )

• neurons in cultured neurospheres show increased migration

behavior/neurological

behavior/neurological phenotype ( J:256961 )

N	• no spontaneous seizures detected after weaning

cellular

abnormal neuronal migration ( J:256961 )

• neurons in cultured neurospheres show increased migration

Allelic Composition	Pcdh19^tm1Tac/Pcdh19⁺
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcdh19^tm1Tac mutation (0 available); any Pcdh19 mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:256961 )

N	• despite expression patterns, brain structure appears normal and cells are located in the expected locations

abnormal brain wave pattern ( J:255320 )

• at P42, electrocorticogram show increase in amplitude, increase in mean number of spike wave discharge events per hour, and increase in duration of spike wave discharge events compared to either homozygous null or wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:256961 )

N	• no spontaneous seizures detected after weaning

Allelic Composition	Pcdh19^tm1Tac/Pcdh19^em1Pqt
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcdh19^em1Pqt mutation (0 available); any Pcdh19 mutation (3 available)
Pcdh19^tm1Tac mutation (0 available); any Pcdh19 mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal forebrain development ( J:255320 )

• protein expressing and null cells form distinct clusters in an alternating pattern from the ventricular zone to the cortical plate

• cell segregation is detected at E10.5 but not at E9.5

Allelic Composition	Pcdh19^tm1Tac/Y
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcdh19^tm1Tac mutation (0 available); any Pcdh19 mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:256961 )

N	• despite expression patterns, brain structure appears normal and cells are located in the expected locations

abnormal neuronal migration ( J:256961 )

• neurons in cultured neurospheres show increased migration

behavior/neurological

behavior/neurological phenotype ( J:256961 )

N	• no spontaneous seizures detected after weaning

cellular

abnormal neuronal migration ( J:256961 )

• neurons in cultured neurospheres show increased migration

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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