Phenotypes associated with this allele

• Allele Symbol: Gripap1^tm1Rlh
• Allele Name: targeted mutation 1, Richard L Huganir
• Allele ID: MGI:6117099
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gripap1^tm1Rlh/Gripap1^tm1Rlh	B6.129-Gripap1^tm1Rlh	MGI:6158527
cx2	Gripap1^tm1Rlh/Gripap1^tm1Rlh Tg(Thy1-EGFP)MJrs/0	involves: 129 * C57BL/6 * C57BL/6J * CBA	MGI:6158528

Genotype
MGI:6158527

hm1

• Allelic Composition: Gripap1^tm1Rlh/Gripap1^tm1Rlh
• Genetic Background: B6.129-Gripap1^tm1Rlh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired active avoidance behavior ( J:256043 )

• shorter step-through latency in light-dark chamber test where mice are introduced in light chamber and had experienced shock during training when crossing into dark chamber

impaired spatial learning ( J:256043 )

• delayed learning of hidden platform location in Morris water maze test

abnormal spatial reference memory ( J:256043 )

• no spatial preference in test where previously introduced platform was removed

nervous system

nervous system phenotype ( J:256043 )

N • long term depression (LTD)

N • paired-pulse ratio (PPR)

reduced long-term potentiation ( J:256043 )

• LTP induction by theta burst stimulation (TBS) results in initially less potentiated field excitatory postsynaptic potential (fEPSP) that remained reduced for at least 1 hr

abnormal miniature excitatory postsynaptic currents ( J:256043 )

• frequency significantly reduced in hippocampal CA1 neurons at age P21-23

• amplitude in hippocampal CA1 neurons at age P21-23

Genotype
MGI:6158528

cx2

• Allelic Composition: Gripap1^tm1Rlh/Gripap1^tm1Rlh; Tg(Thy1-EGFP)MJrs/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

nervous system

abnormal glutaminergic neuron morphology ( J:256043 )

• significant reduction in glutaminergic synapse density, as measured by number of spines on secondary dendrites of hippocampal CA1 neurons at age P21-23