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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		PrkdcM9Btlr
mutation 9, Bruce Beutler
MGI:6114639
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		PrkdcM9Btlr/PrkdcM9Btlr C57BL/6J-PrkdcM9Btlr MGI:6114641
ht2
 		PrkdcM9Btlr/Prkdc+ C57BL/6J-PrkdcM9Btlr MGI:6114642


Genotype
MGI:6114641
hm1
Allelic
Composition		 PrkdcM9Btlr/PrkdcM9Btlr
Genetic
Background		 C57BL/6J-PrkdcM9Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PrkdcM9Btlr mutation (0 available); any Prkdc mutation (399 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B-1a cell number ( J:255268 )
• after mouse cytomegalovirus (MCMV) infection
increased B cell number ( J:255268 )
• B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood after mouse cytomegalovirus (MCMV) infection
increased B-1b cell number ( J:255268 )
• after mouse cytomegalovirus (MCMV) infection
decreased effector memory CD4-positive, alpha-beta T cell number ( J:255268 )
• after mouse cytomegalovirus (MCMV) infection

immune system
decreased B-1a cell number ( J:255268 )
• after mouse cytomegalovirus (MCMV) infection
increased B cell number ( J:255268 )
• B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood after mouse cytomegalovirus (MCMV) infection
increased B-1b cell number ( J:255268 )
• after mouse cytomegalovirus (MCMV) infection
decreased effector memory CD4-positive, alpha-beta T cell number ( J:255268 )
• after mouse cytomegalovirus (MCMV) infection




Genotype
MGI:6114642
ht2
Allelic
Composition		 PrkdcM9Btlr/Prkdc+
Genetic
Background		 C57BL/6J-PrkdcM9Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PrkdcM9Btlr mutation (0 available); any Prkdc mutation (399 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B-1a cell number ( J:255268 )
• after mouse cytomegalovirus (MCMV) infection
increased B cell number ( J:255268 )
• B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood after mouse cytomegalovirus (MCMV) infection
increased B-1b cell number ( J:255268 )
• after mouse cytomegalovirus (MCMV) infection
decreased effector memory CD4-positive, alpha-beta T cell number ( J:255268 )
• after mouse cytomegalovirus (MCMV) infection

hematopoietic system
decreased B-1a cell number ( J:255268 )
• after mouse cytomegalovirus (MCMV) infection
increased B cell number ( J:255268 )
• B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood after mouse cytomegalovirus (MCMV) infection
increased B-1b cell number ( J:255268 )
• after mouse cytomegalovirus (MCMV) infection
decreased effector memory CD4-positive, alpha-beta T cell number ( J:255268 )
• after mouse cytomegalovirus (MCMV) infection




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory