Phenotypes associated with this allele

• Allele Symbol: Wdr4^tm1.1Hsi
• Allele Name: targeted mutation 1.1, Tao-shih Hsieh
• Allele ID: MGI:6114160
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wdr4^tm1.1Hsi/Wdr4^tm1.1Hsi	involves: C57BL/6J * FVB/N	MGI:6114161

Genotype
MGI:6114161

hm1

• Allelic Composition: Wdr4^tm1.1Hsi/Wdr4^tm1.1Hsi
• Genetic Background: involves: C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:230030 )

• by E11.5 no homozygous embryos are found

• at E9.5 and E10.5 abnormal embryos showing varying degrees of resorption are found

embryo

abnormal embryonic tissue physiology ( J:230030 )

• signs of DNA damage are seen in embryos at E9.5

increased embryonic tissue cell apoptosis ( J:230030 )

• at E9.5

cardiovascular system

internal hemorrhage ( J:230030 )

• internal bleeding is seen in some embryos at E10.5

nervous system

abnormal brain development ( J:230030 )

• seen in some survivng embryos at E10.5

cellular

increased embryonic tissue cell apoptosis ( J:230030 )

• at E9.5