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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nlrp3M11Btlr
mutation 11, Bruce Beutler
MGI:6114093
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nlrp3M11Btlr/Nlrp3M11Btlr C57BL/6J-Nlrp3M11Btlr MGI:6114095


Genotype
MGI:6114095
hm1
Allelic
Composition		 Nlrp3M11Btlr/Nlrp3M11Btlr
Genetic
Background		 C57BL/6J-Nlrp3M11Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3M11Btlr mutation (0 available); any Nlrp3 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:255211 )
• decreased secretion of the proinflammatory cytokine interleukin (IL)-1beta in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment (i.e., NLRP3 inflammasome defect)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory