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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gatmm1Btlr
mutation 1, Bruce Beutler
MGI:6113820
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gatmm1Btlr/Gatmm1Btlr C57BL/6J-Gatmm1Btlr MGI:6113845
ht2
 		Gatmm1Btlr/Gatm+ C57BL/6J-Gatmm1Btlr MGI:6113846
ht3
 		Gatmem1Btlr/Gatmm1Btlr C57BL/6J-Gatmem1Btlr/Gatmm1Btlr MGI:6113843


Genotype
MGI:6113845
hm1
Allelic
Composition		 Gatmm1Btlr/Gatmm1Btlr
Genetic
Background		 C57BL/6J-Gatmm1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gatmm1Btlr mutation (0 available); any Gatm mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

digestive/alimentary system
increased enterocyte apoptosis ( J:252049 )
• in the colon of DSS-treated mice
abnormal duodenum crypts of Lieberkuhn morphology ( J:252049 )
• the colons of the DSS-treated mice exhibit loss of crypt architecture, a denuded epithelial layer, and prominent inflammatory infiltrates compared with wild-type mice
decreased colon length ( J:252049 )
• in DSS-treated mice
diarrhea ( J:252049 )
• increased in DSS-treated mice
increased susceptibility to induced colitis ( J:252049 )
• DSS-treated mice exhibit severe muscle wasting, increased weight loss, decreased creatine levels in intestinal epithelium, increased intestinal epithelium permeability, increased colon shortening, diarrhea, rectal bleeding, excessive cell death in the colon and increased mortality compared with wild-type mice
• however, supplementation with creatine reverses muscle wasting and restores body weight while not ameliorating normal DSS-induced colitis

growth/size/body
increased susceptibility to weight loss ( J:252049 )
• in DSS-treated mice
• however, supplementation with creatine reverses muscle wasting and restores body weight

homeostasis/metabolism
decreased creatine level ( J:252049 )
• in the intestinal epithelium of DSS-treated mice

immune system
increased susceptibility to induced colitis ( J:252049 )
• DSS-treated mice exhibit severe muscle wasting, increased weight loss, decreased creatine levels in intestinal epithelium, increased intestinal epithelium permeability, increased colon shortening, diarrhea, rectal bleeding, excessive cell death in the colon and increased mortality compared with wild-type mice
• however, supplementation with creatine reverses muscle wasting and restores body weight while not ameliorating normal DSS-induced colitis

cellular
increased enterocyte apoptosis ( J:252049 )
• in the colon of DSS-treated mice

endocrine/exocrine glands
abnormal duodenum crypts of Lieberkuhn morphology ( J:252049 )
• the colons of the DSS-treated mice exhibit loss of crypt architecture, a denuded epithelial layer, and prominent inflammatory infiltrates compared with wild-type mice




Genotype
MGI:6113846
ht2
Allelic
Composition		 Gatmm1Btlr/Gatm+
Genetic
Background		 C57BL/6J-Gatmm1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gatmm1Btlr mutation (0 available); any Gatm mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

digestive/alimentary system
increased susceptibility to induced colitis ( J:252049 )
• DSS-treated mice increased mortality compared with wild-type mice

homeostasis/metabolism

immune system
increased susceptibility to induced colitis ( J:252049 )
• DSS-treated mice increased mortality compared with wild-type mice




Genotype
MGI:6113843
ht3
Allelic
Composition		 Gatmem1Btlr/Gatmm1Btlr
Genetic
Background		 C57BL/6J-Gatmem1Btlr/Gatmm1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gatmem1Btlr mutation (0 available); any Gatm mutation (21 available)
Gatmm1Btlr mutation (0 available); any Gatm mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
decreased colon length ( J:252049 )
• in DSS-treated mice
diarrhea ( J:252049 )
• increased in DSS-treated mice
increased susceptibility to induced colitis ( J:252049 )
• DSS-treated mice exhibit increased weight loss, diarrhea, rectal bleeding and colonic shortening compared with wild-type mice

growth/size/body
increased susceptibility to weight loss ( J:252049 )
• in DSS-treated mice

immune system
increased susceptibility to induced colitis ( J:252049 )
• DSS-treated mice exhibit increased weight loss, diarrhea, rectal bleeding and colonic shortening compared with wild-type mice




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory