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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ticam2M2Btlr
mutation 2, Bruce Beutler
MGI:6113627
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ticam2M2Btlr/Ticam2M2Btlr C57BL/6J-Ticam2M2Btlr MGI:6113629
ht2
 		Ticam2M2Btlr/Ticam2+ C57BL/6J-Ticam2M2Btlr MGI:6113630


Genotype
MGI:6113629
hm1
Allelic
Composition		 Ticam2M2Btlr/Ticam2M2Btlr
Genetic
Background		 C57BL/6J-Ticam2M2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ticam2M2Btlr mutation (0 available); any Ticam2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:254908 )
• attenuated inflammatory responses related to decreased secretion of the proinflammatory cytokine interleukin (IL)-1beta in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment




Genotype
MGI:6113630
ht2
Allelic
Composition		 Ticam2M2Btlr/Ticam2+
Genetic
Background		 C57BL/6J-Ticam2M2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ticam2M2Btlr mutation (0 available); any Ticam2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:254908 )
• attenuated inflammatory responses related to decreased secretion of the proinflammatory cytokine interleukin (IL)-1beta in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory