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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Card11M4Btlr
mutationn 4, Bruce Beutler
MGI:6113504
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Card11M4Btlr/Card11M4Btlr C57BL/6J-Card11M4Btlr MGI:6113506
ht2
 		Card11M4Btlr/Card11+ C57BL/6J-Card11M4Btlr MGI:6113507


Genotype
MGI:6113506
hm1
Allelic
Composition		 Card11M4Btlr/Card11M4Btlr
Genetic
Background		 C57BL/6J-Card11M4Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card11M4Btlr mutation (0 available); any Card11 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgM level ( J:254856 )
• decreased T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
impaired humoral immune response ( J:254856 )
• decreased T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

hematopoietic system
decreased IgM level ( J:254856 )
• decreased T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)




Genotype
MGI:6113507
ht2
Allelic
Composition		 Card11M4Btlr/Card11+
Genetic
Background		 C57BL/6J-Card11M4Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card11M4Btlr mutation (0 available); any Card11 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory