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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dennd1btm1.1Achn
targeted mutation 1.1, Andrew C Chan
MGI:6113475
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Dennd1btm1.1Achn/Dennd1btm1.1Achn
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * DBA/2 MGI:6115547


Genotype
MGI:6115547
cn1
Allelic
Composition		 Dennd1btm1.1Achn/Dennd1btm1.1Achn
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dennd1btm1.1Achn mutation (0 available); any Dennd1b mutation (65 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
lymph node hyperplasia ( J:229307 )
• increased cell numbers in mediastinal lymph nodes after TNP-OVA immunization

respiratory system
abnormal lung morphology ( J:229307 )
• increased number of lymphocytes, neutrophils, macrophages and eosinophils in BAL fluid and lung tissue after TNP-OVA immunization
• increased TNP-OVA-specific IgE and IgG1 levels in BAL and serum after OVA challenge
enlarged lung ( J:229307 )
• increased cell numbers in lungs and bronchoalveolar lavage (BAL) fluid after TNP-OVA immunization

growth/size/body
enlarged lung ( J:229307 )
• increased cell numbers in lungs and bronchoalveolar lavage (BAL) fluid after TNP-OVA immunization




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory