All Phenotypes Zap70<m6Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Zap70^m6Btlr
mutation 6, Bruce Beutler
MGI:6113448

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zap70^m6Btlr/Zap70^m6Btlr	C57BL/6J-Zap70^m6Btlr	MGI:6113451

Allelic Composition	Zap70^m6Btlr/Zap70^m6Btlr
Genetic Background	C57BL/6J-Zap70^m6Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70^m6Btlr mutation (0 available); any Zap70 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B cell number ( J:254831 )

• B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:254831 )

• in the peripheral blood

increased central memory CD4-positive, alpha-beta T cell number ( J:254831 )

• in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:254831 )

• in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:254831 )

• in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:254831 )

• in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:254831 )

• in the peripheral blood

abnormal humoral immune response ( J:254831 )

• reduced T-dependent antibody response to ovalbumin administered with aluminum hydroxide was diminished

decreased IgG level ( J:254831 )

• reduced T-dependent antibody response to ovalbumin administered with aluminum hydroxide was diminished

hematopoietic system

increased B cell number ( J:254831 )

• B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:254831 )

• in the peripheral blood

increased central memory CD4-positive, alpha-beta T cell number ( J:254831 )

• in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:254831 )

• in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:254831 )

• in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:254831 )

• in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:254831 )

• in the peripheral blood

decreased IgG level ( J:254831 )

• reduced T-dependent antibody response to ovalbumin administered with aluminum hydroxide was diminished

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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