Phenotypes associated with this allele

• Allele Symbol: Tex19.1^tm2.2Ics
• Allele Name: targeted mutation 2.2, Mouse Clinical Institute
• Allele ID: MGI:6110011
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tex19.1^tm2.2Ics/Tex19.1^tm2.2Ics Tex19.2^tm1.2Ics/Tex19.2^tm1.2Ics	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:6110578

Genotype
MGI:6110578

cx1

• Allelic Composition: Tex19.1^tm2.2Ics/Tex19.1^tm2.2Ics; Tex19.2^tm1.2Ics/Tex19.2^tm1.2Ics
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

azoospermia ( J:243444 )

♂ • in epididymis

seminiferous tubule degeneration ( J:243444 )

♂ • tubules contain only early spermatogenic cells, no post-meiotic germ cells

♂ • increased level of apoptosis

decreased testis weight ( J:243444 )

♂ • 3-fold lower weight

testis degeneration ( J:243444 )

♂ • vacuolization and seminiferous epithelium degeneration starting between P10 and P16

abnormal synaptonemal complex ( J:243444 )

♂ • synaptic failure at pachytene stage

arrest of spermatogenesis ( J:243444 )

♂ • between P10 and P16

arrest of male meiosis ( J:243444 )

♂ • persistent double-stranded breaks at pachytene stage

transmission ratio distortion ( J:243444 )

• fewer homozygous mice born than expected from heterozygote interbreeding: 207:440:59 wt:het:hom

male infertility ( J:243444 )

♂

endocrine/exocrine glands

seminiferous tubule degeneration ( J:243444 )

♂ • tubules contain only early spermatogenic cells, no post-meiotic germ cells

♂ • increased level of apoptosis

decreased testis weight ( J:243444 )

♂ • 3-fold lower weight

testis degeneration ( J:243444 )

♂ • vacuolization and seminiferous epithelium degeneration starting between P10 and P16

mortality/aging

postnatal lethality ( J:243444 )

♀ • fewer female than male mice survive: at 2 weeks female:male ratio is 32:68

cellular

azoospermia ( J:243444 )

♂ • in epididymis