Phenotypes associated with this allele

• Allele Symbol: Jak3^m1J
• Allele Name: mutation 1, Jackson
• Allele ID: MGI:6108882
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jak3^m1J/Jak3^m1J	B6.Cg-Crb1^+ Jak3^m1J/Boc	MGI:6257347
cx2	Crb1^rd8+em1Boc/Crb1^rd8+em1Boc Jak3^m1J/Jak3^m1J	B6.Cg-Crb1^rd8+em1Boc Jak3^m1J/Boc	MGI:6258407
cx3	Crb1^rd8/Crb1^rd8 Jak3^m1J/Jak3^m1J	B6.Cg-Crb1^rd8 Jak3^m1J/BocJ	MGI:6257345

Genotype
MGI:6257347

hm1

• Allelic Composition: Jak3^m1J/Jak3^m1J
• Genetic Background: B6.Cg-Crb1⁺ Jak3^m1J/Boc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

small thymus ( J:265859 )

decreased thymus weight ( J:265859 )

• at 3 months of age the average thymus weight is 10.6 mg versus 87.2 mg for wild-type controls

vision/eye

vision/eye phenotype ( J:265859 )

N • normal retinas

hematopoietic system

small thymus ( J:265859 )

decreased thymus weight ( J:265859 )

• at 3 months of age the average thymus weight is 10.6 mg versus 87.2 mg for wild-type controls

small spleen ( J:265859 )

decreased spleen weight ( J:265859 )

• at 3 months of age the average spleen weight is 36.6 mg versus 81 mg for wild-type controls

immune system

small thymus ( J:265859 )

decreased thymus weight ( J:265859 )

• at 3 months of age the average thymus weight is 10.6 mg versus 87.2 mg for wild-type controls

small spleen ( J:265859 )

decreased spleen weight ( J:265859 )

• at 3 months of age the average spleen weight is 36.6 mg versus 81 mg for wild-type controls

Genotype
MGI:6258407

cx2

• Allelic Composition: Crb1^rd8+em1Boc/Crb1^rd8+em1Boc; Jak3^m1J/Jak3^m1J
• Genetic Background: B6.Cg-Crb1^rd8+em1Boc Jak3^m1J/Boc

endocrine/exocrine glands

small thymus ( J:265859 )

vision/eye

vision/eye phenotype ( J:265859 )

N

hematopoietic system

small thymus ( J:265859 )

small spleen ( J:265859 )

immune system

small thymus ( J:265859 )

small spleen ( J:265859 )

Genotype
MGI:6257345

cx3

• Allelic Composition: Crb1^rd8/Crb1^rd8; Jak3^m1J/Jak3^m1J
• Genetic Background: B6.Cg-Crb1^rd8 Jak3^m1J/BocJ

pigmentation

abnormal retina pigment epithelium morphology ( J:265859 )

abnormal retina pigmentation ( J:265859 )

endocrine/exocrine glands

small thymus ( J:265859 )

cardiovascular system

abnormal retina vasculature morphology ( J:265859 )

retina neovascularization ( J:265859 )

hematopoietic system

small thymus ( J:265859 )

small spleen ( J:265859 )

decreased spleen weight ( J:265859 )

immune system

small thymus ( J:265859 )

small spleen ( J:265859 )

decreased spleen weight ( J:265859 )

vision/eye

abnormal retina morphology ( J:265859 )

• at 18 days of age there are areas of retinal depigmentation lacking fluorescein leakage, the number and size of spots increases and some fluorescein leakage is found at 25 days of age, by 3 weeks of age subretinal vascularization and disturbance of the outer retina are found, and eventually the depigmented spots become large areas of depigmentation with aberrant blood vessels spaning from the retinal pigment epithelium to the inner nuclear layer accompanied by photoreceptor cell degeneration

abnormal retina vasculature morphology ( J:265859 )

retina neovascularization ( J:265859 )

abnormal retina pigment epithelium morphology ( J:265859 )

abnormal retina pigmentation ( J:265859 )

retina spots ( J:265859 )

abnormal electroretinogram waveform feature ( J:265859 )

abnormal eye electrophysiology ( J:265859 )

• electroretinograms show a slight reduction in scotopic and photopic responses at 8 weeks of age and larger reduction at 8 months of age

abnormal cone electrophysiology ( J:265859 )

abnormal rod electrophysiology ( J:265859 )