All Phenotypes Kpna7<tm1.1Sgao> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kpna7^tm1.1Sgao/Kpna7^tm1.1Sgao	involves: 129S1/Sv * 129X1/SvJ	MGI:6108356
ht2	Kpna7^tm1.1Sgao/Kpna7⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:6108357

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality before implantation, incomplete penetrance ( J:244973 )

• in culture only 51.6% of zygotes survive to the two-cell stage compared to 92.6% of controls

preweaning lethality, incomplete penetrance ( J:244973 )

• fewer than expected homozygotes are found

• preferential loss of females compared to males

reproductive system

abnormal female germ cell physiology ( J:244973 )

• in a parthenogenesis assay 88.6% (63 of 71) one cell embryos fail to develop into blastocyts by 144h after hCG injection compared to 13.6% of wild-type controls

• in a parthenogenesis assay the first and the second cell cycles occur more rapidly compared to wild-type controls and embryos beyond the 2-cell stage appear fragmented

reduced female fertility ( J:244973 )

decreased litter size ( J:244973 )

• average litter size is 5.8 +/- 3.1 mice/litter compared to 11.1 +/- 2.2 mice/litter for wild-type controls

• many embryos die after E8.5

• impaired reproductive capacity is more severe in older and multigravida females compared to primigravida/young females

• male to female ratio in litters indicates a greater preterm loss of females

cellular

abnormal cell cycle ( J:244973 )

• cell cycles in induced-parthenogenesis and naturally fertilized embryos are ahead of schedule