Analysis Tools
mortality/aging
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• most mice die before E16.5
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cardiovascular system
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• in the ventricles
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• does not display organized clusters of smooth muscle cells or vascular structures unlike wild-type myocardium
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• completely penetrant at E16.5
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• absent
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• distended, abnormally positioned relative to the ventricle
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• rounded without apex
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• reduced trabeculation, thinner compact myocardium and disorganized ventricular myocardium
• reduced myocardial cytokinesis
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• with tearing of the membranous region at E14.5
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• thin with tearing of the membranous region at E14.5
• however, initial development is normal unlike in null mice
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• at E11.5
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• on the surface of the heart at E11.5 and persisting until death at E16.5
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• at E11.5
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homeostasis/metabolism
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• at E11.5
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• at E11.5
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nervous system
hydrocephaly
(
J:248868
)
|
• prominent in the mesencephalic vesicle at E13.5, persisting at E15.5
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skeleton
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• in mice that survive beyond E16.5
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muscle
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• in the ventricles
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• does not display organized clusters of smooth muscle cells or vascular structures unlike wild-type myocardium
|
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• reduced trabeculation, thinner compact myocardium and disorganized ventricular myocardium
• reduced myocardial cytokinesis
|
craniofacial
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• in mice that survive beyond E16.5
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