Phenotypes associated with this allele

• Allele Symbol: Lamb1^Lt
• Allele Name: Lamb1-truncated
• Allele ID: MGI:6107689
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Lamb1^Lt/Lamb1^+	B6N.Cg-Lamb1^Lt	MGI:6107753

Genotype
MGI:6107753

ht1

• Allelic Composition: Lamb1^Lt/Lamb1⁺
• Genetic Background: B6N.Cg-Lamb1^Lt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:247484 )

N • mice exhibit normal walking, climbing and rearing when unstressed in their home cages

abnormal motor capabilities/coordination/movement ( J:247484 )

• motor symptoms are first detected between P17 and P28 with symptoms becoming more persistent between 2 and 6 months

abnormal postural reflex ( J:247484 )

• caudal hypertension when suspended by tail income mice

limb grasping ( J:247484 )

• transient hyperflexion in some mice

dystonia ( J:247484 )

• upon awakening or in novel environments with hyperextension of one or both hindlimbs

• hypertension response when swimming

• dystonic symptoms during forced treadmill running

• however, mice exhibit normal walking, climbing and rearing when unstressed in their home cages

impaired coordination ( J:247484 )

• hindlimb slips on a beam with very affected mice falling off the beam

• increased falling on a rotarod

impaired swimming ( J:247484 )

• hypertension response when swimming

• slower swimming speed than wild-type mice

abnormal limb posture ( J:247484 )

• wide-spreading hindlimbs during sitting

• dystonic symptoms during forced treadmill running

abnormal gait ( J:247484 )

• dystonic symptoms during forced treadmill running

• however, gait is normal on running wheel in home cage

nervous system

nervous system phenotype ( J:247484 )

N • mice exhibit normal brain, spinal cord and spinal root morphology

abnormal single cell response ( J:247484 )

• during abnormal postures, deep cerebellar nuclei and Purkinje cells exhibit irregularly firing neurons with reduced average firing rates and high-frequency bursts compare3d with wild-type cells

• however, firing rates are normal during normal postures

limbs/digits/tail

wavy tail ( J:247484 )

• transiently curvy tails

muscle

dystonia ( J:247484 )

• upon awakening or in novel environments with hyperextension of one or both hindlimbs

• hypertension response when swimming

• dystonic symptoms during forced treadmill running

• however, mice exhibit normal walking, climbing and rearing when unstressed in their home cages