All Phenotypes Moap1<tm1Vcy> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Moap1^tm1Vcy
targeted mutation 1, Victor C Yu
MGI:6104254

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Moap1^tm1Vcy/Moap1^tm1Vcy	B6.129-Moap1^tm1Vcy	MGI:6104262

Allelic Composition	Moap1^tm1Vcy/Moap1^tm1Vcy
Genetic Background	B6.129-Moap1^tm1Vcy

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Moap1^tm1Vcy mutation (0 available); any Moap1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased hepatocyte apoptosis ( J:238373 )

• decreased sensitivity to anti-Fas antibody-induced liver apoptosis

• higher survival rates 24 hours after anti-Fas antibody injection (87% versus 15% wild-type)

• no hemorrhagic lesions

• fewer apoptotic markers

liver/biliary system

decreased hepatocyte apoptosis ( J:238373 )

• decreased sensitivity to anti-Fas antibody-induced liver apoptosis

• higher survival rates 24 hours after anti-Fas antibody injection (87% versus 15% wild-type)

• no hemorrhagic lesions

• fewer apoptotic markers

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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