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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		NischV33A
V33A
MGI:6100940
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		NischV33A/NischV33A involves: BALB/c * C57BL/6J MGI:6101185
ht2
 		Nischedsn/NischV33A involves: BALB/c * C3H/HeH * C57BL/6J MGI:6101184


Genotype
MGI:6101185
hm1
Allelic
Composition		 NischV33A/NischV33A
Genetic
Background		 involves: BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NischV33A mutation (0 available); any Nisch mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
impaired hearing ( J:244907 )
• mild at 8 weeks
increased susceptibility to otitis media ( J:244907 )
• at 12 weeks
• increased intermediate middle ear mucosal thickness that is less severe than in Nischedsn homozygotes and compound heterozygotes

immune system
increased susceptibility to otitis media ( J:244907 )
• at 12 weeks
• increased intermediate middle ear mucosal thickness that is less severe than in Nischedsn homozygotes and compound heterozygotes




Genotype
MGI:6101184
ht2
Allelic
Composition		 Nischedsn/NischV33A
Genetic
Background		 involves: BALB/c * C3H/HeH * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nischedsn mutation (0 available); any Nisch mutation (72 available)
NischV33A mutation (0 available); any Nisch mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased susceptibility to otitis media ( J:244907 )
• onset at 4 weeks, progressive
• increased intermediate middle ear mucosal thickness

immune system
increased susceptibility to otitis media ( J:244907 )
• onset at 4 weeks, progressive
• increased intermediate middle ear mucosal thickness




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory