Analysis Tools
homeostasis/metabolism
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• when fed a high-fat diet (HFD) from 5 to 18 weeks of age, mice weigh significantly less than wild-type controls after 14 weeks, with no significant differences in food or water intake
• after 20 weeks on HFD, mice show significantly lower white adipose tissue (WAT) weight and liver weight than wild-type controls
• no differences in body weight, WAT or liver weight are observed on a normal chow diet
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• after 14 weeks on HFD, fasted mice given an i.p. injection of insulin show significantly lower blood glucose levels than wild-type controls in an ITT test, indicating reduced insulin resistance; however, glucose tolerance is normal
• no differences in insulin sensitivity or glucose tolerance are observed on a normal chow diet
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growth/size/body
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• when fed a high-fat diet (HFD) from 5 to 18 weeks of age, mice weigh significantly less than wild-type controls after 14 weeks, with no significant differences in food or water intake
• after 20 weeks on HFD, mice show significantly lower white adipose tissue (WAT) weight and liver weight than wild-type controls
• no differences in body weight, WAT or liver weight are observed on a normal chow diet
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adipose tissue
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• after 20 weeks on HFD, mice show significantly lower subcutaneous and perirenal WAT weight than wild-type controls
• however, epididymal WAT weight is not significantly altered under a high-fat diet
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liver/biliary system
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• after 20 weeks on HFD, mice show significantly lower liver weight than wild-type controls
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