All Phenotypes Capzb<tm1c(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Capzb^{tm1c(EUCOMM)Wtsi}
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:5925338

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Capzb^{tm1c(EUCOMM)Wtsi}/Capzb^{tm1c(EUCOMM)Wtsi} Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Tg(Atoh1-cre)1Bfri/0	involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL	MGI:6098730
cn2	Capzb^{tm1c(EUCOMM)Wtsi}/Capzb^{tm1c(EUCOMM)Wtsi} Tg(Atoh1-cre)1Bfri/0	involves: C57BL/6N * CBA * SJL	MGI:6098728

Allelic Composition	Capzb^{tm1c(EUCOMM)Wtsi}/Capzb^{tm1c(EUCOMM)Wtsi} Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Tg(Atoh1-cre)1Bfri/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL
Cell Lines	EPD0105_5_A09

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capzb^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Capzb mutation (80 available)
Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze} mutation (8 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Atoh1-cre)1Bfri mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal cochlea morphology ( J:246055 )

• increased actin aggregation in the adherens-junction region and expansion of the apical surface

decreased cochlear hair cell stereocilia number ( J:246055 )

• no distinguishable stereocilia

cochlear hair cell degeneration ( J:246055 )

• reduction in stereocilia diameter and length eventually followed by disappearance

abnormal cuticular plate morphology ( J:246055 )

• ruptures

abnormal vestibular hair cell stereociliary bundle morphology ( J:246055 )

• disrupted hair cell in some bundles

short vestibular hair cell stereocilia ( J:246055 )

• with decreased width

nervous system

decreased cochlear hair cell stereocilia number ( J:246055 )

• no distinguishable stereocilia

cochlear hair cell degeneration ( J:246055 )

• reduction in stereocilia diameter and length eventually followed by disappearance

abnormal vestibular hair cell stereociliary bundle morphology ( J:246055 )

• disrupted hair cell in some bundles

short vestibular hair cell stereocilia ( J:246055 )

• with decreased width

Allelic Composition	Capzb^{tm1c(EUCOMM)Wtsi}/Capzb^{tm1c(EUCOMM)Wtsi} Tg(Atoh1-cre)1Bfri/0
Genetic Background	involves: C57BL/6N * CBA * SJL
Cell Lines	EPD0105_5_A09

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capzb^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Capzb mutation (80 available)
Tg(Atoh1-cre)1Bfri mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:246055 )

absent distortion product otoacoustic emissions ( J:246055 )

abnormal vestibular system physiology ( J:246055 )

• strongly reduced vestibular function

absent linear vestibular evoked potential ( J:246055 )

• undetectable in 4 of 5 mice

behavior/neurological

head shaking ( J:246055 )

• progressively worse after weaning

• however, mice do not exhibit circling

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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