Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(Bcor*A)Vjba}
• Allele Name: targeted mutation 1, Vivian J Bardwell
• Allele ID: MGI:5925311
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(Bcor*A)Vjba/Gt(ROSA)26Sor^tm1(Bcor*A)Vjba	involves: 129S1/Sv	MGI:5925313
cn2	Gt(ROSA)26Sor^tm1(Bcor*A)Vjba/Gt(ROSA)26Sor^+ Tmem163^Tg(ACTB-cre)2Mrt/Tmem163^+	involves: 129S1/Sv * FVB/N	MGI:7344054

Genotype
MGI:5925313

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Bcor*A)Vjba}/Gt(ROSA)26Sor^{tm1(Bcor*A)Vjba}
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased cell proliferation ( J:231455 )

• bone marrow cells cultured under myeloid stem/progenitor conditions and infected with a cre expression retrovirus exhibit decreased proliferative rate

hematopoietic system

abnormal bone marrow cell physiology ( J:231455 )

• bone marrow cells cultured under myeloid stem/progenitor conditions and infected with a cre expression retrovirus exhibit decreased proliferative rate

Genotype
MGI:7344054

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Bcor*A)Vjba}/Gt(ROSA)26Sor⁺; Tmem163^{Tg(ACTB-cre)2Mrt}/Tmem163⁺
• Genetic Background: involves: 129S1/Sv * FVB/N

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:296645 )

• embryos die between E10.5 and E14.5 with all dead by E14.5

craniofacial

short mandible ( J:296645 )

• short and misshapen

short snout ( J:296645 )

• short and misshapen

vision/eye

abnormal eye morphology ( J:296645 )

• misshapen by E12.5

limbs/digits/tail

abnormal forelimb morphology ( J:296645 )

• small and misshapen by E13.5

nervous system

abnormal hindbrain morphology ( J:296645 )

• appears bulbous

skeleton

short mandible ( J:296645 )

• short and misshapen

growth/size/body

short mandible ( J:296645 )

• short and misshapen

short snout ( J:296645 )

• short and misshapen