Phenotypes associated with this allele

• Allele Symbol: Lrig3^tm1.1Hhed
• Allele Name: targeted mutation 1.1, Hakan Hedman
• Allele ID: MGI:5911996
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrig3^tm1.1Hhed/Lrig3^tm1.1Hhed	B6.129(Cg)-Lrig3^tm1.1Hhed	MGI:5912045

Genotype
MGI:5912045

hm1

• Allelic Composition: Lrig3^tm1.1Hhed/Lrig3^tm1.1Hhed
• Genetic Background: B6.129(Cg)-Lrig3^tm1.1Hhed

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart left ventricle morphology ( J:242435 , J:242435 )

• at 6 months; reduced diastolic inner diameter (J:242435)

♀ • at 12 months; thicker left ventricular septal and posterior walls (J:242435)

abnormal heart left ventricle weight ( J:242435 )

♀ • at 12 months; increased ratio versus body weight

decreased cardiac output ( J:242435 )

♀ • at 12 months

decreased cardiac stroke volume ( J:242435 )

♀ • at 12 months

increased heart rate ( J:242435 )

♂ • at 6 months

increased systemic arterial blood pressure ( J:242435 )

• at 12 months; 109.7 vs 105.6 mmHg in wild-type

homeostasis/metabolism

decreased circulating insulin level ( J:242435 )

• at 9 months

decreased circulating HDL cholesterol level ( J:242435 )

• at 12 months; reduced by 12% and 9% in female and male, respectively

decreased circulating glycerol level ( J:242435 )

♂ • at 12 months; 22% reduction

growth/size/body

decreased body size ( J:242435 )

• at 12 months as measured by right tibia length

decreased body weight ( J:242435 )

• at 12 months