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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pkn1tm1Ajmc
targeted mutation 1, Angus JM Cameron
MGI:5911979
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pkn1tm1Ajmc/Pkn1tm1Ajmc B6.129P2-Pkn1tm1Ajmc MGI:5912002
cx2
 		Pkn1tm1Ajmc/Pkn1tm1Ajmc
Pkn2tm1a(KOMP)Wtsi/Pkn2+
Pkn3tm1Ajmc/Pkn3tm1Ajmc 		involves: 129P2/OlaHsd * C57BL/6N * C57BL/6NTac MGI:5912007
cx3
 		Pkn1tm1Ajmc/Pkn1tm1Ajmc
Pkn3tm1Ajmc/Pkn3tm1Ajmc 		involves: 129P2/OlaHsd * C57BL/6NTac MGI:5912005


Genotype
MGI:5912002
hm1
Allelic
Composition		 Pkn1tm1Ajmc/Pkn1tm1Ajmc
Genetic
Background		 B6.129P2-Pkn1tm1Ajmc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkn1tm1Ajmc mutation (0 available); any Pkn1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiovascular system physiology ( J:258572 )
• hearts show a significant decrease in p42/p44-MAPK (ERK1/2) phosphorylation both at baseline and during global ischemia and reperfusion (I/R)
decreased cardiac muscle contractility ( J:258572 )
• the maximal rate of systolic pressure development (dP/dT max) normalized to the end diastolic pressure (EDP) is significantly lower than that in wild-type hearts
• however, the average dP/dTmax and ejection fraction are relatively normal
decreased cardiac muscle relaxation ( J:258572 )
• the maximal rate of relaxation (dP/dT min) normalized to the end diastolic pressure (EDP) is significantly lower than that in wild-type hearts
abnormal heart echocardiography feature ( J:258572 )
• Doppler echocardiography revealed that left ventricular (LV) posterior wall thickness at diastole (PWTD) is significantly higher than that in wild-type hearts
decreased left ventricle developed pressure ( J:258572 )
• following I/R, LVDP is significantly lower than that in wild-type hearts (17.7 +/- 3.9% versus 33.6 +/- 6.1%) with no differences in end diastolic pressure (EDP) or coronary flow (CF), indicating increased injury and reduced functional recovery
• however, baseline LVDP, EDP and CF are normal
decreased left ventricle systolic pressure ( J:258572 )
• beat-to-beat systolic pressure (SP) normalized to the end diastolic pressure (EDP) is significantly lower than that in wild-type hearts
increased myocardial infarct size ( J:258572 )
• following global I/R injury, myocardial infarct size is nearly doubled relative to that in wild-type hearts (45.1 +/- 2.9% versus 25.5 +/- 0.8%)

homeostasis/metabolism
increased myocardial infarct size ( J:258572 )
• following global I/R injury, myocardial infarct size is nearly doubled relative to that in wild-type hearts (45.1 +/- 2.9% versus 25.5 +/- 0.8%)
abnormal calcium ion homeostasis ( J:258572 )
• hearts show a significant increase in basal phospholamban (PLB) Thr17 phosphorylation, ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2, aka SERCA2) expression and Jph2 (junctophilin-2) expression, suggesting a compensatory enhancement of sarcoplasmic reticulum Ca2+ uptake at baseline

muscle
decreased cardiac muscle contractility ( J:258572 )
• the maximal rate of systolic pressure development (dP/dT max) normalized to the end diastolic pressure (EDP) is significantly lower than that in wild-type hearts
• however, the average dP/dTmax and ejection fraction are relatively normal
decreased cardiac muscle relaxation ( J:258572 )
• the maximal rate of relaxation (dP/dT min) normalized to the end diastolic pressure (EDP) is significantly lower than that in wild-type hearts

mortality/aging
mortality/aging ( J:229595 )
N
• mice are viable and overtly normal

reproductive system
reproductive system phenotype ( J:229595 )
N
• mice are fertile




Genotype
MGI:5912007
cx2
Allelic
Composition		 Pkn1tm1Ajmc/Pkn1tm1Ajmc
Pkn2tm1a(KOMP)Wtsi/Pkn2+
Pkn3tm1Ajmc/Pkn3tm1Ajmc
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6N * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkn1tm1Ajmc mutation (0 available); any Pkn1 mutation (45 available)
Pkn2tm1a(KOMP)Wtsi mutation (1 available); any Pkn2 mutation (84 available)
Pkn3tm1Ajmc mutation (0 available); any Pkn3 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:229595 )
• viable and fertile with no overt phenotype




Genotype
MGI:5912005
cx3
Allelic
Composition		 Pkn1tm1Ajmc/Pkn1tm1Ajmc
Pkn3tm1Ajmc/Pkn3tm1Ajmc
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkn1tm1Ajmc mutation (0 available); any Pkn1 mutation (45 available)
Pkn3tm1Ajmc mutation (0 available); any Pkn3 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:229595 )
• viable and fertile with no overt phenotype




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory